Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival

Calixto Hope G. Lucas; Harish N. Vasudevan; William C. Chen; Stephen T. Magill; Steve E. Braunstein; Line Jacques; Sonika Dahiya; Fausto J. Rodriguez; Andrew E. Horvai; Arie Perry; Melike Pekmezci; David R. Raleigh

doi:10.1093/noajnl/vdaa131

Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival

Calixto Hope G. Lucas, Harish N. Vasudevan, William C. Chen, Stephen T. Magill, Steve E. Braunstein, Line Jacques, Sonika Dahiya, Fausto J. Rodriguez, Andrew E. Horvai, Arie Perry, Melike Pekmezci^*, David R. Raleigh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive and poorly understood malignant neoplasm. Even in the setting of multimodal therapy, the clinical course of MPNST is frequently marked by metastatic conversion and poor overall prognosis, with optimal treatment paradigms for this rare tumor unknown. Methods: We reviewed the medical records and histopathology of 54 consecutive patients who were treated at University of California San Francisco between 1990 and 2018. Results: Our cohort consisted of 24 male and 30 female patients (median age 38 years).

Original language	English (US)
Article number	vdaa131
Journal	Neuro-Oncology Advances
Volume	2
Issue number	1
DOIs	https://doi.org/10.1093/noajnl/vdaa131
State	Published - Jan 1 2020
Externally published	Yes

Keywords

FCrossed D sign©dCrossed D sign©ration Nationale des Centres de Lutte Contre Le Cancer
clinical outcomes
immunohistochemistry
malignant peripheral nerve sheath tumor
radiotherapy

ASJC Scopus subject areas

Clinical Neurology
Oncology
Surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/noajnl/vdaa131

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Lucas, C. H. G., Vasudevan, H. N., Chen, W. C., Magill, S. T., Braunstein, S. E., Jacques, L., Dahiya, S., Rodriguez, F. J., Horvai, A. E., Perry, A., Pekmezci, M., & Raleigh, D. R. (2020). Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival. Neuro-Oncology Advances, 2(1), [vdaa131]. https://doi.org/10.1093/noajnl/vdaa131

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title = "Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival",

abstract = "Background: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive and poorly understood malignant neoplasm. Even in the setting of multimodal therapy, the clinical course of MPNST is frequently marked by metastatic conversion and poor overall prognosis, with optimal treatment paradigms for this rare tumor unknown. Methods: We reviewed the medical records and histopathology of 54 consecutive patients who were treated at University of California San Francisco between 1990 and 2018. Results: Our cohort consisted of 24 male and 30 female patients (median age 38 years).",

keywords = "FCrossed D sign{\textcopyright}dCrossed D sign{\textcopyright}ration Nationale des Centres de Lutte Contre Le Cancer, clinical outcomes, immunohistochemistry, malignant peripheral nerve sheath tumor, radiotherapy",

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year = "2020",

month = jan,

day = "1",

doi = "10.1093/noajnl/vdaa131",

language = "English (US)",

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T1 - Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival

AU - Lucas, Calixto Hope G.

AU - Vasudevan, Harish N.

AU - Chen, William C.

AU - Magill, Stephen T.

AU - Braunstein, Steve E.

AU - Jacques, Line

AU - Dahiya, Sonika

AU - Rodriguez, Fausto J.

AU - Horvai, Andrew E.

AU - Perry, Arie

AU - Pekmezci, Melike

AU - Raleigh, David R.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Background: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive and poorly understood malignant neoplasm. Even in the setting of multimodal therapy, the clinical course of MPNST is frequently marked by metastatic conversion and poor overall prognosis, with optimal treatment paradigms for this rare tumor unknown. Methods: We reviewed the medical records and histopathology of 54 consecutive patients who were treated at University of California San Francisco between 1990 and 2018. Results: Our cohort consisted of 24 male and 30 female patients (median age 38 years).

AB - Background: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive and poorly understood malignant neoplasm. Even in the setting of multimodal therapy, the clinical course of MPNST is frequently marked by metastatic conversion and poor overall prognosis, with optimal treatment paradigms for this rare tumor unknown. Methods: We reviewed the medical records and histopathology of 54 consecutive patients who were treated at University of California San Francisco between 1990 and 2018. Results: Our cohort consisted of 24 male and 30 female patients (median age 38 years).

KW - clinical outcomes

KW - immunohistochemistry

KW - malignant peripheral nerve sheath tumor

KW - radiotherapy

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Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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