Histopathology of SPINK-1 Hereditary Pancreatitis

Christopher Felicelli*, Maryam K. Pezhouh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Hereditary pancreatitis is a rare form of recurrent acute pancreatitis that typically has an onset in early adulthood. We report a rare case of hereditary pancreatitis in an individual with a serine protease inhibitor Kazal type 1 (SPINK1) mutation. Histologically the pancreas showed features of chronic pancreatitis with variable fibrosis, acinar destruction, and prominent inspissated secretions within the pancreatic ducts. Additionally, focal areas of low-grade pancreatic intraepithelial neoplasia (PanIN) were present. Although the histopathology of common gene mutations resulting in hereditary pancreatitis have been well described, the histopathology of pancreatitis secondary to SPINK1 mutation has been described in only one previous study.

Original languageEnglish (US)
JournalInternational Journal of Surgical Pathology
StateAccepted/In press - 2020


  • hereditary pancreatitis
  • histology
  • histopathology
  • pancreatitis
  • SPINK1

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Histopathology of SPINK-1 Hereditary Pancreatitis'. Together they form a unique fingerprint.

Cite this