HIV-1 capsid: The multifaceted key player in HIV-1 infection

Edward M. Campbell, Thomas J. Hope

Research output: Contribution to journalReview articlepeer-review

240 Scopus citations

Abstract

In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core made from the viral capsid (CA) protein. The CA protein and the structure into which it assembles facilitate virtually every step of infection through a series of interactions with multiple host cell factors. This Review describes our understanding of the interactions between the viral capsid core and several cellular factors that enable efficient HIV-1 genome replication, timely core disassembly, nuclear import and the integration of the viral genome into the genome of the target cell. We then discuss how elucidating these interactions can reveal new targets for therapeutic interactions against HIV-1.

Original languageEnglish (US)
Pages (from-to)471-483
Number of pages13
JournalNature Reviews Microbiology
Volume13
Issue number8
DOIs
StatePublished - Jul 16 2015

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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