HIV-1 infection: No evidence of cognitive decline during the asymptomatic stages

The Multicenter AIDS Cohort Study Neuropsychologic Working Group

Research output: Contribution to journalArticle

160 Scopus citations

Abstract

Cross-sectional studies have not adequately resolved the question of whether subjects infected with HIV-1 may suffer cognitive decline during the early, asymptomatic stages of the infection. We studied longitudinally 238 asymptomatic healthy HIV-1-infected homosexual/bisexual men (CDC groups 2 and 3) and 170 uninfected controls in the Multicenter AIDS Cohort Study with neuropsychological testing at semiannual intervals. A comparison of change in scores between visits 1 and 4 as well as a multivariate autoregressive analysis revealed no evidence of decline in test performance over time in the HIV-1-infected group compared with the seronegative controls. These findings suggest that a gradual cognitive decline does not occur during the early, asymptomatic stages of HIV infection.

Original languageEnglish (US)
Pages (from-to)204-208
Number of pages5
JournalNeurology
Volume40
Issue number2
DOIs
StatePublished - Feb 1990

ASJC Scopus subject areas

  • Clinical Neurology

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    The Multicenter AIDS Cohort Study Neuropsychologic Working Group (1990). HIV-1 infection: No evidence of cognitive decline during the asymptomatic stages. Neurology, 40(2), 204-208. https://doi.org/10.1212/wnl.40.2.204