HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

Philippe Gallay, Thomas Hope, Daniel Chin, Didier Trono*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

402 Scopus citations

Abstract

The karyophilic properties of the HIV-1 nucleoprotein complex facilitate infection of nondividing cells such as macrophages and quiescent T lymphocytes, and allow the in vivo delivery of transgenes by HIV-derived retroviral vectors into terminally differentiated cells such as neurons. Although the viral matrix (MA) and Vpr proteins have previously been shown to play important roles in this process, we demonstrate here that integrase, the enzyme responsible for mediating the integration of the viral genome in the host cell chromosome, can suffice to connect the HIV-1 preintegration complex with the cell nuclear import machinery. This novel function of integrase reflects the recognition of an atypical bipartite nuclear localization signal by the importin/karyopherin pathway.

Original languageEnglish (US)
Pages (from-to)9825-9830
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number18
DOIs
StatePublished - Sep 2 1997

Keywords

  • Human immunodeficiency virus
  • Nuclear import

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway'. Together they form a unique fingerprint.

Cite this