HIV-1 Sequence Variation Between Isolates from Mother-Infant Transmission Pairs

Carla M. Wike, Bette T m Korber, Michael R. Daniels, Cecelia Hutto, Jose Muñoz, Manohar Furtado, Wade Parks, Alfred Saah, Marc Bulterys, Jean Baptiste Kurawige, Steven M. Wolinsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

To examine the sequence diversity of human immunodeficiency virus type 1 (HIV-1) between known transmission sets, sequences from the V3 and V4-V5 region of the envelope gene from four mother-infant pairs were analyzed. The mean interpatient sequence variation between isolates from linked mother-infant pairs was comparable to the sequence diversity found between isolates from other close contacts. The mean intrapatient variation was significantly less in the infants' isolates then the isolates from both their mothers and other characterized intrapatient sequence sets. In addition, a distinct and characteristic difference in the glycosylation pattern preceding the V3 loop was found between each linked transmission pair. These findings indicate that selection of specific genotypic variants, which may play a role in some direct transmission sets, and the duration of infection are important factors in the degree of diversity seen between the sequence sets.

Original languageEnglish (US)
Pages (from-to)1297-1300
Number of pages4
JournalAIDS research and human retroviruses
Volume8
Issue number7
DOIs
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Immunology

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