HIV accessory proteins and surviving the host cell.

Jenny L. Anderson*, Thomas J. Hope

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Human immunodeficiency virus generates the accessory proteins Nef, viral infectivity factor (Vif), viral protein R, and viral protein U or viral protein X during viral replication in host cells. Although the significance of these accessory proteins is often lost in vitro, they are essential for viral pathogenesis in vivo. Therefore, these proteins have much potential as antiviral targets. Recent data reveal Vif perturbs an ill-defined antiviral pathway in host cells allowing HIV replication. These data highlight a common feature among HIV accessory proteins in manipulating the host to aid viral pathogenesis. Therefore, these new insights into Vif and other HIV accessory proteins are reviewed, emphasizing host cell interactions and new targets for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalCurrent HIV/AIDS Reports
Issue number1
StatePublished - Apr 2004

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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