HIV and anal cancer outcomes

A single institution's experience

Melissa E. Hogg, Daniel A. Popowich, Ed C. Wang, Kristina D. Kiel, Steven J. Stryker, Amy L Halverson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

PURPOSE: The purpose of this study is to identify the effect of HIV status on outcome of treatment for squamous-cell carcinoma of the anal canal. METHODS: A retrospective review was performed on all patients with squamous-cell carcinoma of the anal canal treated at a single academic institution between January 1996 and December 2006. RESULTS: Our search identified 87 (21 HIV-positive) patients who had invasive squamous-cell cancer. The median follow-up was 38 months. Eighty-five percent of HIV-negative patients and 81 percent of HIV-positive were identified as complete responders at 6 weeks after completion of combined modality therapy. Eight percent of HIV-negative and 29 percent of HIV-positive patients developed recurrent disease after 6 months (P = 0.0009). Overall survival for HIV-negative and HIV-positive patients was 71 percent and 73 percent, respectively. CONCLUSIONS: HIV-positive patients respond equally to combined modality therapy but have recurrences more frequently than patients who are HIV negative. Overall survival in these two groups is equivalent.

Original languageEnglish (US)
Pages (from-to)891-897
Number of pages7
JournalDiseases of the Colon and Rectum
Volume52
Issue number5
DOIs
StatePublished - May 1 2009

Fingerprint

Anus Neoplasms
HIV
Combined Modality Therapy
Anal Canal
Squamous Cell Carcinoma
Squamous Cell Neoplasms
Survival

Keywords

  • Anal canal cancer
  • Combined modality therapy
  • HIV
  • Squamous-cell carcinoma

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hogg, Melissa E. ; Popowich, Daniel A. ; Wang, Ed C. ; Kiel, Kristina D. ; Stryker, Steven J. ; Halverson, Amy L. / HIV and anal cancer outcomes : A single institution's experience. In: Diseases of the Colon and Rectum. 2009 ; Vol. 52, No. 5. pp. 891-897.
@article{706112a0e7394e67aa56665bdccf9486,
title = "HIV and anal cancer outcomes: A single institution's experience",
abstract = "PURPOSE: The purpose of this study is to identify the effect of HIV status on outcome of treatment for squamous-cell carcinoma of the anal canal. METHODS: A retrospective review was performed on all patients with squamous-cell carcinoma of the anal canal treated at a single academic institution between January 1996 and December 2006. RESULTS: Our search identified 87 (21 HIV-positive) patients who had invasive squamous-cell cancer. The median follow-up was 38 months. Eighty-five percent of HIV-negative patients and 81 percent of HIV-positive were identified as complete responders at 6 weeks after completion of combined modality therapy. Eight percent of HIV-negative and 29 percent of HIV-positive patients developed recurrent disease after 6 months (P = 0.0009). Overall survival for HIV-negative and HIV-positive patients was 71 percent and 73 percent, respectively. CONCLUSIONS: HIV-positive patients respond equally to combined modality therapy but have recurrences more frequently than patients who are HIV negative. Overall survival in these two groups is equivalent.",
keywords = "Anal canal cancer, Combined modality therapy, HIV, Squamous-cell carcinoma",
author = "Hogg, {Melissa E.} and Popowich, {Daniel A.} and Wang, {Ed C.} and Kiel, {Kristina D.} and Stryker, {Steven J.} and Halverson, {Amy L}",
year = "2009",
month = "5",
day = "1",
doi = "10.1007/DCR.0b013e31819eefa6",
language = "English (US)",
volume = "52",
pages = "891--897",
journal = "Diseases of the Colon and Rectum",
issn = "0012-3706",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

HIV and anal cancer outcomes : A single institution's experience. / Hogg, Melissa E.; Popowich, Daniel A.; Wang, Ed C.; Kiel, Kristina D.; Stryker, Steven J.; Halverson, Amy L.

In: Diseases of the Colon and Rectum, Vol. 52, No. 5, 01.05.2009, p. 891-897.

Research output: Contribution to journalArticle

TY - JOUR

T1 - HIV and anal cancer outcomes

T2 - A single institution's experience

AU - Hogg, Melissa E.

AU - Popowich, Daniel A.

AU - Wang, Ed C.

AU - Kiel, Kristina D.

AU - Stryker, Steven J.

AU - Halverson, Amy L

PY - 2009/5/1

Y1 - 2009/5/1

N2 - PURPOSE: The purpose of this study is to identify the effect of HIV status on outcome of treatment for squamous-cell carcinoma of the anal canal. METHODS: A retrospective review was performed on all patients with squamous-cell carcinoma of the anal canal treated at a single academic institution between January 1996 and December 2006. RESULTS: Our search identified 87 (21 HIV-positive) patients who had invasive squamous-cell cancer. The median follow-up was 38 months. Eighty-five percent of HIV-negative patients and 81 percent of HIV-positive were identified as complete responders at 6 weeks after completion of combined modality therapy. Eight percent of HIV-negative and 29 percent of HIV-positive patients developed recurrent disease after 6 months (P = 0.0009). Overall survival for HIV-negative and HIV-positive patients was 71 percent and 73 percent, respectively. CONCLUSIONS: HIV-positive patients respond equally to combined modality therapy but have recurrences more frequently than patients who are HIV negative. Overall survival in these two groups is equivalent.

AB - PURPOSE: The purpose of this study is to identify the effect of HIV status on outcome of treatment for squamous-cell carcinoma of the anal canal. METHODS: A retrospective review was performed on all patients with squamous-cell carcinoma of the anal canal treated at a single academic institution between January 1996 and December 2006. RESULTS: Our search identified 87 (21 HIV-positive) patients who had invasive squamous-cell cancer. The median follow-up was 38 months. Eighty-five percent of HIV-negative patients and 81 percent of HIV-positive were identified as complete responders at 6 weeks after completion of combined modality therapy. Eight percent of HIV-negative and 29 percent of HIV-positive patients developed recurrent disease after 6 months (P = 0.0009). Overall survival for HIV-negative and HIV-positive patients was 71 percent and 73 percent, respectively. CONCLUSIONS: HIV-positive patients respond equally to combined modality therapy but have recurrences more frequently than patients who are HIV negative. Overall survival in these two groups is equivalent.

KW - Anal canal cancer

KW - Combined modality therapy

KW - HIV

KW - Squamous-cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=67651165227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651165227&partnerID=8YFLogxK

U2 - 10.1007/DCR.0b013e31819eefa6

DO - 10.1007/DCR.0b013e31819eefa6

M3 - Article

VL - 52

SP - 891

EP - 897

JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

SN - 0012-3706

IS - 5

ER -