HIV and Stem Cell Transplantation

Ignacio A. Echenique, George E. Nelson, Valentina Stosor, Christine M. Durand*

*Corresponding author for this work

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

In human immunodeficiency virus (HIV)-infected persons, the incidence of hematologic malignancies, including leukemia and lymphoma, is increased despite the use of successful antiretroviral therapy. Hematopoietic stem cell transplantation (SCT) is emerging as a safe and effective therapy for HIV-infected persons with hematologic malignancies. Management of these patients is complicated by drug–drug interactions involving antiretroviral therapy (ART) that may impact conditioning agent efficacy and metabolism of immunosuppressive medications and potentiate drug toxicities. As such, optimal strategies for ART remain controversial. We discuss recent advances, controversies, and future directions related to SCT in HIV-infected persons, including the investigation of allogeneic SCT as a strategy for HIV cure.

Original languageEnglish (US)
Article number424
Pages (from-to)1-10
Number of pages10
JournalCurrent Infectious Disease Reports
Volume16
Issue number9
DOIs
StatePublished - Sep 1 2014

Keywords

  • AIDS
  • Allogeneic stem cell transplantation
  • Antiretroviral therapy
  • Autologous stem cell transplantation
  • Bone marrow transplantation
  • GVHD
  • HIV
  • HIV cure
  • HIV eradication
  • HIV reservoir
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
  • Stem cell transplantation

ASJC Scopus subject areas

  • Infectious Diseases

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  • Cite this

    Echenique, I. A., Nelson, G. E., Stosor, V., & Durand, C. M. (2014). HIV and Stem Cell Transplantation. Current Infectious Disease Reports, 16(9), 1-10. [424]. https://doi.org/10.1007/s11908-014-0424-y