HIV Neuropathy—a Review of Mechanisms, Diagnosis, and Treatment of Pain

Kaitlyn E. Egan; Gregory M. Caldwell; Maxim S. Eckmann

doi:10.1007/s11916-021-00971-2

HIV Neuropathy—a Review of Mechanisms, Diagnosis, and Treatment of Pain

Kaitlyn E. Egan^*, Gregory M. Caldwell, Maxim S. Eckmann

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Purpose of Review: This article is a systematic review of data from 2018 to 2020 regarding information from publications on epidemiologic, diagnostic, and therapeutic advancements in human immunodeficiency virus–associated peripheral neuropathy. Recent Findings: The epidemiology/pathology of HIV neuropathy is discussed. Diagnostics includes skin wrinkling-eutectic mixture of local anesthetic test and neurologic examinations. Therapeutic interventions include pharmacologic and nonpharmacologic management as well as self-management strategies. Summary: Peripheral neuropathy continues to affect the lives of persons living with HIV. First-line treatment with pregabalin or gabapentin for HIV neuropathic pain has limited data on adequate response. Exercise and self-management strategies may provide benefit in pain reduction. Continuing research on risk factors and biomarkers for HIV-related peripheral neuropathy will be critical for future diagnostic and therapeutic agents.

Original language	English (US)
Article number	55
Journal	Current Pain and Headache Reports
Volume	25
Issue number	8
DOIs	https://doi.org/10.1007/s11916-021-00971-2
State	Published - Aug 2021

Keywords

HIV
Human immunodeficiency virus
Neuropathic
Neuropathy
Pain
Treatment

ASJC Scopus subject areas

Clinical Neurology
Anesthesiology and Pain Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11916-021-00971-2

Cite this

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title = "HIV Neuropathy—a Review of Mechanisms, Diagnosis, and Treatment of Pain",

abstract = "Purpose of Review: This article is a systematic review of data from 2018 to 2020 regarding information from publications on epidemiologic, diagnostic, and therapeutic advancements in human immunodeficiency virus–associated peripheral neuropathy. Recent Findings: The epidemiology/pathology of HIV neuropathy is discussed. Diagnostics includes skin wrinkling-eutectic mixture of local anesthetic test and neurologic examinations. Therapeutic interventions include pharmacologic and nonpharmacologic management as well as self-management strategies. Summary: Peripheral neuropathy continues to affect the lives of persons living with HIV. First-line treatment with pregabalin or gabapentin for HIV neuropathic pain has limited data on adequate response. Exercise and self-management strategies may provide benefit in pain reduction. Continuing research on risk factors and biomarkers for HIV-related peripheral neuropathy will be critical for future diagnostic and therapeutic agents.",

keywords = "HIV, Human immunodeficiency virus, Neuropathic, Neuropathy, Pain, Treatment",

author = "Egan, {Kaitlyn E.} and Caldwell, {Gregory M.} and Eckmann, {Maxim S.}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2021",

month = aug,

doi = "10.1007/s11916-021-00971-2",

language = "English (US)",

volume = "25",

journal = "Current Pain and Headache Reports",

issn = "1531-3433",

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number = "8",

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T1 - HIV Neuropathy—a Review of Mechanisms, Diagnosis, and Treatment of Pain

AU - Egan, Kaitlyn E.

AU - Caldwell, Gregory M.

AU - Eckmann, Maxim S.

PY - 2021/8

Y1 - 2021/8

N2 - Purpose of Review: This article is a systematic review of data from 2018 to 2020 regarding information from publications on epidemiologic, diagnostic, and therapeutic advancements in human immunodeficiency virus–associated peripheral neuropathy. Recent Findings: The epidemiology/pathology of HIV neuropathy is discussed. Diagnostics includes skin wrinkling-eutectic mixture of local anesthetic test and neurologic examinations. Therapeutic interventions include pharmacologic and nonpharmacologic management as well as self-management strategies. Summary: Peripheral neuropathy continues to affect the lives of persons living with HIV. First-line treatment with pregabalin or gabapentin for HIV neuropathic pain has limited data on adequate response. Exercise and self-management strategies may provide benefit in pain reduction. Continuing research on risk factors and biomarkers for HIV-related peripheral neuropathy will be critical for future diagnostic and therapeutic agents.

AB - Purpose of Review: This article is a systematic review of data from 2018 to 2020 regarding information from publications on epidemiologic, diagnostic, and therapeutic advancements in human immunodeficiency virus–associated peripheral neuropathy. Recent Findings: The epidemiology/pathology of HIV neuropathy is discussed. Diagnostics includes skin wrinkling-eutectic mixture of local anesthetic test and neurologic examinations. Therapeutic interventions include pharmacologic and nonpharmacologic management as well as self-management strategies. Summary: Peripheral neuropathy continues to affect the lives of persons living with HIV. First-line treatment with pregabalin or gabapentin for HIV neuropathic pain has limited data on adequate response. Exercise and self-management strategies may provide benefit in pain reduction. Continuing research on risk factors and biomarkers for HIV-related peripheral neuropathy will be critical for future diagnostic and therapeutic agents.

KW - HIV

KW - Human immunodeficiency virus

KW - Neuropathic

KW - Neuropathy

KW - Pain

KW - Treatment

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HIV Neuropathy—a Review of Mechanisms, Diagnosis, and Treatment of Pain

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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