HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

Sarah E. Benner; Xianming Zhu; Sarah Hussain; Sander Florman; Yolanda Eby; Reinaldo E. Fernandez; Darin Ostrander; Meenakshi Rana; Shane Ottmann; Jonathan Hand; Jennifer C. Price; Marcus R. Pereira; David Wojciechowski; Jacques Simkins; Valentina Stosor; Sapna A. Mehta; Saima Aslam; Maricar Malinis; Ghady Haidar; Allan Massie; Melissa L. Smith; Jonah Odim; Megan Morsheimer; Thomas C. Quinn; Gregory M. Laird; Robert Siliciano; Ashwin Balagopal; Dorry L. Segev; Christine M. Durand; Andrew D. Redd; Aaron A.R. Tobian

doi:10.1093/infdis/jiad241

HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

Sarah E. Benner, Xianming Zhu, Sarah Hussain, Sander Florman, Yolanda Eby, Reinaldo E. Fernandez, Darin Ostrander, Meenakshi Rana, Shane Ottmann, Jonathan Hand, Jennifer C. Price, Marcus R. Pereira, David Wojciechowski, Jacques Simkins, Valentina Stosor, Sapna A. Mehta, Saima Aslam, Maricar Malinis, Ghady Haidar, Allan MassieMelissa L. Smith, Jonah Odim, Megan Morsheimer, Thomas C. Quinn, Gregory M. Laird, Robert Siliciano, Ashwin Balagopal, Dorry L. Segev, Christine M. Durand, Andrew D. Redd^*, Aaron A.R. Tobian

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV.

Original language	English (US)
Pages (from-to)	1274-1279
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	228
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiad241
State	Published - Nov 1 2023

Funding

Financial support. This work was supported by the National Institute of Allergy and Infectious Diseases (NIAID) (grant numbers 1R01AI120938, U01AI134591, U24AI143502, and U01AI138897); the National Institute of Diabetes, Digestive and Kidney Diseases (grant number 1R01DK131926); and the Division of Intramural Research, NIAID, National Institutes of Health. A special thank you to the organ donors, families, and recipients who made this study possible. We also thank Diane Brown, Natasha Watson, and the HOPE in Action laboratory and clinical trial teams for their hard work and assistance with this project. We thank Kristen Ritter, Mignot Mathias, Miriam Hays, and Hanna Marks for their work on sample processing and virologic testing with this project. We also thank Northwestern University, Leah Goudy, RN and Michelle Callegari; University of Miami School of Medicine, Isabel Vital and Lissettt Moni; University of Pittsbugh, Kailey Hughes Kramer; University of California San Diego, Phirum Nguyen and Jeff Mills; New York University Lagone Health, Rebecca Dieter PharmD; and Ochsner Health, Angela Smith, MBA. This work was supported by the National Institute of Allergy and Infectious Diseases (NIAID) (grant numbers 1R01AI120938, U01AI134591, U24AI143502, and U01AI138897); the National Institute of Diabetes, Digestive and Kidney Diseases (grant number 1R01DK131926); and the Division of Intramural Research, NIAID, National Institutes of Health.

Keywords

HIV
HIV cure
latent viral reservoir
liver
organ transplant

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Benner, S. E., Zhu, X., Hussain, S., Florman, S., Eby, Y., Fernandez, R. E., Ostrander, D., Rana, M., Ottmann, S., Hand, J., Price, J. C., Pereira, M. R., Wojciechowski, D., Simkins, J., Stosor, V., Mehta, S. A., Aslam, S., Malinis, M., Haidar, G., ... Tobian, A. A. R. (2023). HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV. Journal of Infectious Diseases, 228(9), 1274-1279. https://doi.org/10.1093/infdis/jiad241

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title = "HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV",

abstract = "The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV.",

keywords = "HIV, HIV cure, latent viral reservoir, liver, organ transplant",

author = "Benner, {Sarah E.} and Xianming Zhu and Sarah Hussain and Sander Florman and Yolanda Eby and Fernandez, {Reinaldo E.} and Darin Ostrander and Meenakshi Rana and Shane Ottmann and Jonathan Hand and Price, {Jennifer C.} and Pereira, {Marcus R.} and David Wojciechowski and Jacques Simkins and Valentina Stosor and Mehta, {Sapna A.} and Saima Aslam and Maricar Malinis and Ghady Haidar and Allan Massie and Smith, {Melissa L.} and Jonah Odim and Megan Morsheimer and Quinn, {Thomas C.} and Laird, {Gregory M.} and Robert Siliciano and Ashwin Balagopal and Segev, {Dorry L.} and Durand, {Christine M.} and Redd, {Andrew D.} and Tobian, {Aaron A.R.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Societ of America.",

year = "2023",

month = nov,

day = "1",

doi = "10.1093/infdis/jiad241",

language = "English (US)",

volume = "228",

pages = "1274--1279",

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Benner, SE, Zhu, X, Hussain, S, Florman, S, Eby, Y, Fernandez, RE, Ostrander, D, Rana, M, Ottmann, S, Hand, J, Price, JC, Pereira, MR, Wojciechowski, D, Simkins, J, Stosor, V, Mehta, SA, Aslam, S, Malinis, M, Haidar, G, Massie, A, Smith, ML, Odim, J, Morsheimer, M, Quinn, TC, Laird, GM, Siliciano, R, Balagopal, A, Segev, DL, Durand, CM, Redd, AD & Tobian, AAR 2023, 'HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV', Journal of Infectious Diseases, vol. 228, no. 9, pp. 1274-1279. https://doi.org/10.1093/infdis/jiad241

TY - JOUR

T1 - HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

AU - Benner, Sarah E.

AU - Zhu, Xianming

AU - Hussain, Sarah

AU - Florman, Sander

AU - Eby, Yolanda

AU - Fernandez, Reinaldo E.

AU - Ostrander, Darin

AU - Rana, Meenakshi

AU - Ottmann, Shane

AU - Hand, Jonathan

AU - Price, Jennifer C.

AU - Pereira, Marcus R.

AU - Wojciechowski, David

AU - Simkins, Jacques

AU - Stosor, Valentina

AU - Mehta, Sapna A.

AU - Aslam, Saima

AU - Malinis, Maricar

AU - Haidar, Ghady

AU - Massie, Allan

AU - Smith, Melissa L.

AU - Odim, Jonah

AU - Morsheimer, Megan

AU - Quinn, Thomas C.

AU - Laird, Gregory M.

AU - Siliciano, Robert

AU - Balagopal, Ashwin

AU - Segev, Dorry L.

AU - Durand, Christine M.

AU - Redd, Andrew D.

AU - Tobian, Aaron A.R.

PY - 2023/11/1

Y1 - 2023/11/1

N2 - The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV.

AB - The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV.

KW - HIV

KW - HIV cure

KW - latent viral reservoir

KW - liver

KW - organ transplant

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U2 - 10.1093/infdis/jiad241

DO - 10.1093/infdis/jiad241

M3 - Article

C2 - 37379584

AN - SCOPUS:85176495603

SN - 0022-1899

VL - 228

SP - 1274

EP - 1279

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 9

ER -

HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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