HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

Sarah E. Benner, Xianming Zhu, Sarah Hussain, Sander Florman, Yolanda Eby, Reinaldo E. Fernandez, Darin Ostrander, Meenakshi Rana, Shane Ottmann, Jonathan Hand, Jennifer C. Price, Marcus R. Pereira, David Wojciechowski, Jacques Simkins, Valentina Stosor, Sapna A. Mehta, Saima Aslam, Maricar Malinis, Ghady Haidar, Allan MassieMelissa L. Smith, Jonah Odim, Megan Morsheimer, Thomas C. Quinn, Gregory M. Laird, Robert Siliciano, Ashwin Balagopal, Dorry L. Segev, Christine M. Durand, Andrew D. Redd*, Aaron A.R. Tobian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV.

Original languageEnglish (US)
Pages (from-to)1274-1279
Number of pages6
JournalJournal of Infectious Diseases
Volume228
Issue number9
DOIs
StatePublished - Nov 1 2023

Keywords

  • HIV
  • HIV cure
  • latent viral reservoir
  • liver
  • organ transplant

ASJC Scopus subject areas

  • General Medicine

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