HIV Response Interventions that Integrate HIV Molecular Cluster and Social Network Analysis: A Systematic Review

Daniel J. Gore, Kellie Schueler, Santhoshini Ramani, Arno Uvin, Gregory Phillips, Moira McNulty, Kayo Fujimoto, John Schneider*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Due to improved efficiency and reduced cost of viral sequencing, molecular cluster analysis can be feasibly utilized alongside existing human immunodeficiency virus (HIV) prevention strategies. The goal of this paper is to elucidate how HIV molecular cluster and social network analyses are being integrated to implement HIV response interventions. We searched PubMed, Scopus, PsycINFO, and Cochrane Library databases for studies incorporating both HIV molecular cluster and social network data. We identified 32 articles that combined analyses of HIV molecular sequences and social or sexual networks. All studies were descriptive. Six studies described network interventions informed by molecular and social data but did not fully evaluate their efficacy. There is no current standard for incorporating molecular and social network analyses to inform interventions or data demonstrating its utility. More research must be conducted to delineate benefits and best practices for leveraging molecular data for network-based interventions.

Original languageEnglish (US)
Pages (from-to)1750-1792
Number of pages43
JournalAIDS and behavior
Volume26
Issue number6
DOIs
StateAccepted/In press - 2021

Keywords

  • Cluster analysis
  • Cluster detection and response
  • Contact tracing
  • HIV
  • Social networks
  • Systematic review

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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