Abstract
It remains unclear whether differences in gut microbiota noted between HIV-infected and uninfected individuals are driven by HIV or sexual behavior. We evaluated rectal swab microbiota of HIV-infected and uninfected women with similar demographic, neighborhood, and diet characteristics enrolled in the Chicago Women's Interagency HIV Study (WIHS). DNA was amplified for sequencing of fragments of bacterial small subunit (SSU or 16S) ribosomal RNA (rRNA) genes. HIV-infected and uninfected women did not differ by Shannon diversity index (p = .14), non-metric multidimensional scaling (NMDS) plot of Bray-Curtis indices (p = .488, r = 0.0027), or copy number of individual taxa. Both groups demonstrated marked microbiome stability over time (p = .889).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 260-266 |
| Number of pages | 7 |
| Journal | AIDS research and human retroviruses |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2019 |
Funding
Data in this article were collected by the WIHS. WIHS (Principal Investigators): Chicago WIHS (A.F.; Mardge Cohen), U01-AI-034993. The WIHS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute on Mental Health (NIMH). This study was presented at the International AIDS Society in Paris, July 2017, abstract A-854-0029-04135.
Keywords
- HIV
- microbiome
- mucosal immunology
- women
ASJC Scopus subject areas
- Immunology
- Virology
- Infectious Diseases
