HIV viral load monitoring frequency and risk of treatment failure among immunologically stable HIV-infected patients prescribed combination antiretroviral therapy

Benjamin Young; Rachel L.D. Hart; Kate Buchacz; M. Scott; Frank Palella; John T. Brooks

doi:10.1177/2325957415600799

HIV viral load monitoring frequency and risk of treatment failure among immunologically stable HIV-infected patients prescribed combination antiretroviral therapy

Benjamin Young^*, Rachel L.D. Hart, Kate Buchacz, M. Scott, Frank Palella, John T. Brooks

^*Corresponding author for this work

Medicine, Infectious Diseases Division

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8 Scopus citations

Abstract

The authors sought to assess whether viral load (VL) monitoring frequency was associated with differential rates of virologic failure (VF) among HIV Outpatient Study (HOPS) participants seen during 1999 to 2013, who had maintained VL <50 copies/mL, CD4 counts ≥300 cells/mm³, and been prescribed a stable combination antiretroviral regimen for at least 2 years. The authors required VL and CD4 testing to have occurred regularly for the entire 2-year period. The authors assessed rates of VF comparing patients who maintained a frequent VL testing (≥3 VLs) to those who shifted to a less frequent schedule (2 VL) after the 2-year period. Virologic failure was observed among 116 of 573 participants. The authors did not detect statistically significant difference in frequency of VF among patients undergoing frequent (21.0%) versus less frequent VL testing (19.6%), even after multivariable adjustment. Biannual VL monitoring for stable patients with aviremia could generate substantial cost savings without the increased risk of VF.

Original language	English (US)
Pages (from-to)	536-543
Number of pages	8
Journal	Journal of the International Association of Providers of AIDS Care
Volume	14
Issue number	6
DOIs	https://doi.org/10.1177/2325957415600799
State	Published - Nov 1 2015

Funding

The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: BY has received consulting or speaking fees from Bristol-Myers Squibb, Gilead Sciences, Merck & Co., and ViiV Healthcare. BY has received research funding from Gilead Sciences and ViiV Healthcare. FP has received consulting or speaking fees from Bristol-Myers Squibb, Gilead Sciences, Janssen Pharmaceuticals and Merck & Co. FP has received research funding from Gilead Sciences. MS, RLDH, KB, and JTB do not have any associations that may pose a conflict of interest. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Centers for Disease Control and Prevention (contract nos. 200-2001-00133, 200-2006-18797 and 200-2011-41872). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

Keywords

HIV
diagnostics
viral load

ASJC Scopus subject areas

Infectious Diseases
Dermatology
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Young, B., Hart, R. L. D., Buchacz, K., Scott, M., Palella, F., & Brooks, J. T. (2015). HIV viral load monitoring frequency and risk of treatment failure among immunologically stable HIV-infected patients prescribed combination antiretroviral therapy. Journal of the International Association of Providers of AIDS Care, 14(6), 536-543. https://doi.org/10.1177/2325957415600799

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abstract = "The authors sought to assess whether viral load (VL) monitoring frequency was associated with differential rates of virologic failure (VF) among HIV Outpatient Study (HOPS) participants seen during 1999 to 2013, who had maintained VL <50 copies/mL, CD4 counts ≥300 cells/mm3, and been prescribed a stable combination antiretroviral regimen for at least 2 years. The authors required VL and CD4 testing to have occurred regularly for the entire 2-year period. The authors assessed rates of VF comparing patients who maintained a frequent VL testing (≥3 VLs) to those who shifted to a less frequent schedule (2 VL) after the 2-year period. Virologic failure was observed among 116 of 573 participants. The authors did not detect statistically significant difference in frequency of VF among patients undergoing frequent (21.0%) versus less frequent VL testing (19.6%), even after multivariable adjustment. Biannual VL monitoring for stable patients with aviremia could generate substantial cost savings without the increased risk of VF.",

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Young, B, Hart, RLD, Buchacz, K, Scott, M, Palella, F & Brooks, JT 2015, 'HIV viral load monitoring frequency and risk of treatment failure among immunologically stable HIV-infected patients prescribed combination antiretroviral therapy', Journal of the International Association of Providers of AIDS Care, vol. 14, no. 6, pp. 536-543. https://doi.org/10.1177/2325957415600799

HIV viral load monitoring frequency and risk of treatment failure among immunologically stable HIV-infected patients prescribed combination antiretroviral therapy. / Young, Benjamin; Hart, Rachel L.D.; Buchacz, Kate et al.
In: Journal of the International Association of Providers of AIDS Care, Vol. 14, No. 6, 01.11.2015, p. 536-543.

Research output: Contribution to journal › Article › peer-review

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HIV viral load monitoring frequency and risk of treatment failure among immunologically stable HIV-infected patients prescribed combination antiretroviral therapy

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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