Abstract
Purpose:To report the first documented case of HLA-A29-positive birdshot chorioretinopathy in an African American patient.Methods:A 51-year-old African American woman presented with a 10-year history of photopsia, progressive decrease in visual acuity, metamorphopsia, and new nyctalopia. Both fundi showed evidence of periphlebitis, arterial attenuation, macular edema, and diffuse chorioretinal atrophy.Results:Fluorescein angiography revealed diffuse vascular leakage, and indocyanine green showed evenly distributed and symmetrical hypofluorescent spots, which were difficult to appreciate on fundoscopy. Workup revealed a positive HLA-A29 and was negative for sarcoid, tuberculosis, and syphilis.Conclusion:Birdshot chorioretinopathy overwhelmingly affects non-Hispanic Caucasians, but there have been rare reported cases in other ethnicities including Hispanics and African Americans. This patient's ethnicity may have contributed to the 10-year delay in diagnosis. To our knowledge, this is the first documented HLA-A29 positive case of birdshot chorioretinopathy in an African American. HLA-A29 may be a useful supportive test in cases with classic clinical presentation in non-Caucasian patients to enable the correct diagnose in a timely manner.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 201-204 |
| Number of pages | 4 |
| Journal | Retinal Cases and Brief Reports |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2016 |
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Keywords
- HLA-A29
- birdshot
- choroiditis
- choroidopathy
- race
- uveitis
ASJC Scopus subject areas
- Ophthalmology
Cite this
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HLA-A29-Positive Birdshot Chorioretinopathy in An African American Patient. / Knezevic, Alexander; Munk, Marion R.; Pappas, Frankie; Merrill, Pauline T.; Goldstein, Debra A.
In: Retinal Cases and Brief Reports, Vol. 10, No. 3, 01.01.2016, p. 201-204.Research output: Contribution to journal › Article
TY - JOUR
T1 - HLA-A29-Positive Birdshot Chorioretinopathy in An African American Patient
AU - Knezevic, Alexander
AU - Munk, Marion R.
AU - Pappas, Frankie
AU - Merrill, Pauline T.
AU - Goldstein, Debra A.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Purpose:To report the first documented case of HLA-A29-positive birdshot chorioretinopathy in an African American patient.Methods:A 51-year-old African American woman presented with a 10-year history of photopsia, progressive decrease in visual acuity, metamorphopsia, and new nyctalopia. Both fundi showed evidence of periphlebitis, arterial attenuation, macular edema, and diffuse chorioretinal atrophy.Results:Fluorescein angiography revealed diffuse vascular leakage, and indocyanine green showed evenly distributed and symmetrical hypofluorescent spots, which were difficult to appreciate on fundoscopy. Workup revealed a positive HLA-A29 and was negative for sarcoid, tuberculosis, and syphilis.Conclusion:Birdshot chorioretinopathy overwhelmingly affects non-Hispanic Caucasians, but there have been rare reported cases in other ethnicities including Hispanics and African Americans. This patient's ethnicity may have contributed to the 10-year delay in diagnosis. To our knowledge, this is the first documented HLA-A29 positive case of birdshot chorioretinopathy in an African American. HLA-A29 may be a useful supportive test in cases with classic clinical presentation in non-Caucasian patients to enable the correct diagnose in a timely manner.
AB - Purpose:To report the first documented case of HLA-A29-positive birdshot chorioretinopathy in an African American patient.Methods:A 51-year-old African American woman presented with a 10-year history of photopsia, progressive decrease in visual acuity, metamorphopsia, and new nyctalopia. Both fundi showed evidence of periphlebitis, arterial attenuation, macular edema, and diffuse chorioretinal atrophy.Results:Fluorescein angiography revealed diffuse vascular leakage, and indocyanine green showed evenly distributed and symmetrical hypofluorescent spots, which were difficult to appreciate on fundoscopy. Workup revealed a positive HLA-A29 and was negative for sarcoid, tuberculosis, and syphilis.Conclusion:Birdshot chorioretinopathy overwhelmingly affects non-Hispanic Caucasians, but there have been rare reported cases in other ethnicities including Hispanics and African Americans. This patient's ethnicity may have contributed to the 10-year delay in diagnosis. To our knowledge, this is the first documented HLA-A29 positive case of birdshot chorioretinopathy in an African American. HLA-A29 may be a useful supportive test in cases with classic clinical presentation in non-Caucasian patients to enable the correct diagnose in a timely manner.
KW - HLA-A29
KW - birdshot
KW - choroiditis
KW - choroidopathy
KW - race
KW - uveitis
UR - http://www.scopus.com/inward/record.url?scp=84973360923&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973360923&partnerID=8YFLogxK
U2 - 10.1097/ICB.0000000000000224
DO - 10.1097/ICB.0000000000000224
M3 - Article
C2 - 26579592
AN - SCOPUS:84973360923
VL - 10
SP - 201
EP - 204
JO - Retinal Cases and Brief Reports
JF - Retinal Cases and Brief Reports
SN - 1935-1089
IS - 3
ER -