HLA-A29-Positive Birdshot Chorioretinopathy in An African American Patient

Alexander Knezevic, Marion R. Munk, Frankie Pappas, Pauline T. Merrill, Debra A. Goldstein*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose:To report the first documented case of HLA-A29-positive birdshot chorioretinopathy in an African American patient.Methods:A 51-year-old African American woman presented with a 10-year history of photopsia, progressive decrease in visual acuity, metamorphopsia, and new nyctalopia. Both fundi showed evidence of periphlebitis, arterial attenuation, macular edema, and diffuse chorioretinal atrophy.Results:Fluorescein angiography revealed diffuse vascular leakage, and indocyanine green showed evenly distributed and symmetrical hypofluorescent spots, which were difficult to appreciate on fundoscopy. Workup revealed a positive HLA-A29 and was negative for sarcoid, tuberculosis, and syphilis.Conclusion:Birdshot chorioretinopathy overwhelmingly affects non-Hispanic Caucasians, but there have been rare reported cases in other ethnicities including Hispanics and African Americans. This patient's ethnicity may have contributed to the 10-year delay in diagnosis. To our knowledge, this is the first documented HLA-A29 positive case of birdshot chorioretinopathy in an African American. HLA-A29 may be a useful supportive test in cases with classic clinical presentation in non-Caucasian patients to enable the correct diagnose in a timely manner.

Original languageEnglish (US)
Pages (from-to)201-204
Number of pages4
JournalRetinal Cases and Brief Reports
Volume10
Issue number3
DOIs
StatePublished - Jan 1 2016

Fingerprint

African Americans
Night Blindness
Phlebitis
Indocyanine Green
Macular Edema
Fluorescein Angiography
Vision Disorders
Syphilis
Hispanic Americans
Visual Acuity
Atrophy
Blood Vessels
Tuberculosis
Birdshot chorioretinopathy
HLA-A29 antigen

Keywords

  • HLA-A29
  • birdshot
  • choroiditis
  • choroidopathy
  • race
  • uveitis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Knezevic, Alexander ; Munk, Marion R. ; Pappas, Frankie ; Merrill, Pauline T. ; Goldstein, Debra A. / HLA-A29-Positive Birdshot Chorioretinopathy in An African American Patient. In: Retinal Cases and Brief Reports. 2016 ; Vol. 10, No. 3. pp. 201-204.
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HLA-A29-Positive Birdshot Chorioretinopathy in An African American Patient. / Knezevic, Alexander; Munk, Marion R.; Pappas, Frankie; Merrill, Pauline T.; Goldstein, Debra A.

In: Retinal Cases and Brief Reports, Vol. 10, No. 3, 01.01.2016, p. 201-204.

Research output: Contribution to journalArticle

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