TY - JOUR
T1 - HLA class I and class II alleles and haplotypes in Mexican mestizos established from serological typing of 50 families
AU - De Leo, Claudia
AU - Castelan, Natalia
AU - Lopez, Mayra
AU - Gonzalez, Norma
AU - Weckmann, Ana Luisa
AU - Melin-Aldana, Hector
AU - Vargas-Alarcon, Gilberto
AU - Bordes, Javler
AU - Alarcon-Segovia, Donato
AU - Granados, Julio
AU - Ramirez, Eva
AU - Lisker, Ruben
PY - 1997/12/1
Y1 - 1997/12/1
N2 - We describe new information on the frequency and association of class II antigens (HLA-DR and HLA-DQ) of the major histocompatibility complex (MHC) in Mexicans. The study includes HLA-B typing and its association with the HLA-DR antigens determined in 50 families, which included 100 individuals. This family study allowed the establishment of the precise composition of the 200 HLA haplotypes, which cannot be obtained from unrelated individuals. The predominant antigens in decreasing order of frequency were B35, B39, and B61 at the B locus; DR4, DR5, and DR8 at the DR locus; and DQ3 at the DQ locus. The most common HLA-B, HLA-DR haplotype (considering broad specificities) was B16, DR4, with a frequency of 8.0%. Five HLA-B, HLA-DR haplotypes showed significant delta values (observed vs. expected frequencies) after correcting for the number of comparisons. On the other hand, the most common HLA-DR, HLA-DQ haplotypes were DR4, DQ3 and DR5, DQ3 with a frequency higher than 10%. Ten of the 17 HLA-DR, HLA-DQ haplotypes had significant postcorrection delta values.
AB - We describe new information on the frequency and association of class II antigens (HLA-DR and HLA-DQ) of the major histocompatibility complex (MHC) in Mexicans. The study includes HLA-B typing and its association with the HLA-DR antigens determined in 50 families, which included 100 individuals. This family study allowed the establishment of the precise composition of the 200 HLA haplotypes, which cannot be obtained from unrelated individuals. The predominant antigens in decreasing order of frequency were B35, B39, and B61 at the B locus; DR4, DR5, and DR8 at the DR locus; and DQ3 at the DQ locus. The most common HLA-B, HLA-DR haplotype (considering broad specificities) was B16, DR4, with a frequency of 8.0%. Five HLA-B, HLA-DR haplotypes showed significant delta values (observed vs. expected frequencies) after correcting for the number of comparisons. On the other hand, the most common HLA-DR, HLA-DQ haplotypes were DR4, DQ3 and DR5, DQ3 with a frequency higher than 10%. Ten of the 17 HLA-DR, HLA-DQ haplotypes had significant postcorrection delta values.
KW - HLA
KW - Haplotypes
KW - Linkage disequillibrium
KW - Mexican population
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M3 - Article
C2 - 9353976
AN - SCOPUS:0031543483
VL - 69
SP - 809
EP - 818
JO - Human Biology
JF - Human Biology
SN - 0018-7143
IS - 6
ER -