HLA class I and class II alleles and haplotypes in Mexican mestizos established from serological typing of 50 families

Claudia De Leo, Natalia Castelan, Mayra Lopez, Norma Gonzalez, Ana Luisa Weckmann, Hector Melin-Aldana, Gilberto Vargas-Alarcon, Javler Bordes, Donato Alarcon-Segovia, Julio Granados*, Eva Ramirez, Ruben Lisker

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We describe new information on the frequency and association of class II antigens (HLA-DR and HLA-DQ) of the major histocompatibility complex (MHC) in Mexicans. The study includes HLA-B typing and its association with the HLA-DR antigens determined in 50 families, which included 100 individuals. This family study allowed the establishment of the precise composition of the 200 HLA haplotypes, which cannot be obtained from unrelated individuals. The predominant antigens in decreasing order of frequency were B35, B39, and B61 at the B locus; DR4, DR5, and DR8 at the DR locus; and DQ3 at the DQ locus. The most common HLA-B, HLA-DR haplotype (considering broad specificities) was B16, DR4, with a frequency of 8.0%. Five HLA-B, HLA-DR haplotypes showed significant delta values (observed vs. expected frequencies) after correcting for the number of comparisons. On the other hand, the most common HLA-DR, HLA-DQ haplotypes were DR4, DQ3 and DR5, DQ3 with a frequency higher than 10%. Ten of the 17 HLA-DR, HLA-DQ haplotypes had significant postcorrection delta values.

Original languageEnglish (US)
Pages (from-to)809-818
Number of pages10
JournalHuman Biology
Volume69
Issue number6
StatePublished - Dec 1 1997

Keywords

  • HLA
  • Haplotypes
  • Linkage disequillibrium
  • Mexican population

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

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    De Leo, C., Castelan, N., Lopez, M., Gonzalez, N., Weckmann, A. L., Melin-Aldana, H., Vargas-Alarcon, G., Bordes, J., Alarcon-Segovia, D., Granados, J., Ramirez, E., & Lisker, R. (1997). HLA class I and class II alleles and haplotypes in Mexican mestizos established from serological typing of 50 families. Human Biology, 69(6), 809-818.