Hole-burning diffusion measurements in high magnetic field gradients

E. E. Sigmund*, W. P. Halperin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We describe methods for the measurement of translational diffusion in very large static magnetic field gradients by NMR. The techniques use a "hole-burning" sequence that, with the use of fringe field gradients of 42T/m, can image diffusion along one dimension on a submicron scale. Two varieties of this method are demonstrated, including a particularly efficient mode called the "hole-comb," in which multiple diffusion times comprising an entire diffusive evolution can be measured within the span of a single detected slice. The advantages and disadvantages of these methods are discussed, as well as their potential for addressing non-Fickian diffusion, diffusion in restricted media, and spatially inhomogeneous diffusion.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalJournal of Magnetic Resonance
Issue number1
StatePublished - Jul 2003


  • Diffusion
  • Fringe field
  • Hole-burning
  • NMR

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Nuclear and High Energy Physics
  • Biophysics
  • Biochemistry


Dive into the research topics of 'Hole-burning diffusion measurements in high magnetic field gradients'. Together they form a unique fingerprint.

Cite this