Hole transport in DNA hairpins via base mismatches and strand crossings: Efficiency and dynamics

Arun K. Thazhathveetil; Michelle A. Harris; Ryan M. Young; Michael R. Wasielewski; Frederick D. Lewis

doi:10.1016/j.jphotochem.2016.03.002

Hole transport in DNA hairpins via base mismatches and strand crossings: Efficiency and dynamics

Arun K. Thazhathveetil, Michelle A. Harris, Ryan M. Young, Michael R. Wasielewski^*, Frederick D. Lewis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The efficiency and dynamics of hole transport via base mismatches and strand crossings have been determined for 10 DNA hairpins by means of femtosecond transient absorption spectroscopy. The hairpins possess a stilbenedicarboxamide hole donor and stilbenediether hole acceptor separated by seven base pairs. Hole transport occurs via an intra- or interstrand A₃G₄ diblock purine sequence that contains either a single base pair mismatch or strand crossing. Pyrimidine-pyrimidine mismatches (TT or CC) effectively block intrastrand hole transport; whereas purine-purine mismatches (AA or GG) permit efficient interstrand hole transport. Purine-to-purine intrastrand hole transport between adjacent matched base pairs is also moderately efficient (AG > AA > GG). Based upon these results AA mismatches are being employed in the design of three-way junctions for incorporation in prototype charge splitting and charge combining devices.

Original language	English (US)
Pages (from-to)	160-164
Number of pages	5
Journal	Journal of Photochemistry and Photobiology A: Chemistry
Volume	331
DOIs	https://doi.org/10.1016/j.jphotochem.2016.03.002
State	Published - Dec 1 2016

Keywords

Base-pair mismatch
DNA
Donor-acceptor systems
Hole transport
Transient absorption spectroscopy

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)
Physics and Astronomy(all)

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title = "Hole transport in DNA hairpins via base mismatches and strand crossings: Efficiency and dynamics",

abstract = "The efficiency and dynamics of hole transport via base mismatches and strand crossings have been determined for 10 DNA hairpins by means of femtosecond transient absorption spectroscopy. The hairpins possess a stilbenedicarboxamide hole donor and stilbenediether hole acceptor separated by seven base pairs. Hole transport occurs via an intra- or interstrand A3G4 diblock purine sequence that contains either a single base pair mismatch or strand crossing. Pyrimidine-pyrimidine mismatches (TT or CC) effectively block intrastrand hole transport; whereas purine-purine mismatches (AA or GG) permit efficient interstrand hole transport. Purine-to-purine intrastrand hole transport between adjacent matched base pairs is also moderately efficient (AG > AA > GG). Based upon these results AA mismatches are being employed in the design of three-way junctions for incorporation in prototype charge splitting and charge combining devices.",

keywords = "Base-pair mismatch, DNA, Donor-acceptor systems, Hole transport, Transient absorption spectroscopy",

author = "Thazhathveetil, {Arun K.} and Harris, {Michelle A.} and Young, {Ryan M.} and Wasielewski, {Michael R.} and Lewis, {Frederick D.}",

note = "Funding Information: This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences, and Biosciences Division under Award DE-FG02-96ER14604 (F.D.L.) and the U.S. Office of Naval Research MURI grant no. N00014-11-1-0729 (M.R.W.). Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

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doi = "10.1016/j.jphotochem.2016.03.002",

language = "English (US)",

volume = "331",

pages = "160--164",

journal = "Journal of Photochemistry and Photobiology A: Chemistry",

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Hole transport in DNA hairpins via base mismatches and strand crossings : Efficiency and dynamics. / Thazhathveetil, Arun K.; Harris, Michelle A.; Young, Ryan M.; Wasielewski, Michael R.; Lewis, Frederick D.

In: Journal of Photochemistry and Photobiology A: Chemistry, Vol. 331, 01.12.2016, p. 160-164.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Hole transport in DNA hairpins via base mismatches and strand crossings

T2 - Efficiency and dynamics

AU - Thazhathveetil, Arun K.

AU - Harris, Michelle A.

AU - Young, Ryan M.

AU - Wasielewski, Michael R.

AU - Lewis, Frederick D.

N1 - Funding Information: This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences, and Biosciences Division under Award DE-FG02-96ER14604 (F.D.L.) and the U.S. Office of Naval Research MURI grant no. N00014-11-1-0729 (M.R.W.). Publisher Copyright: © 2016 Elsevier B.V.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - The efficiency and dynamics of hole transport via base mismatches and strand crossings have been determined for 10 DNA hairpins by means of femtosecond transient absorption spectroscopy. The hairpins possess a stilbenedicarboxamide hole donor and stilbenediether hole acceptor separated by seven base pairs. Hole transport occurs via an intra- or interstrand A3G4 diblock purine sequence that contains either a single base pair mismatch or strand crossing. Pyrimidine-pyrimidine mismatches (TT or CC) effectively block intrastrand hole transport; whereas purine-purine mismatches (AA or GG) permit efficient interstrand hole transport. Purine-to-purine intrastrand hole transport between adjacent matched base pairs is also moderately efficient (AG > AA > GG). Based upon these results AA mismatches are being employed in the design of three-way junctions for incorporation in prototype charge splitting and charge combining devices.

AB - The efficiency and dynamics of hole transport via base mismatches and strand crossings have been determined for 10 DNA hairpins by means of femtosecond transient absorption spectroscopy. The hairpins possess a stilbenedicarboxamide hole donor and stilbenediether hole acceptor separated by seven base pairs. Hole transport occurs via an intra- or interstrand A3G4 diblock purine sequence that contains either a single base pair mismatch or strand crossing. Pyrimidine-pyrimidine mismatches (TT or CC) effectively block intrastrand hole transport; whereas purine-purine mismatches (AA or GG) permit efficient interstrand hole transport. Purine-to-purine intrastrand hole transport between adjacent matched base pairs is also moderately efficient (AG > AA > GG). Based upon these results AA mismatches are being employed in the design of three-way junctions for incorporation in prototype charge splitting and charge combining devices.

KW - Base-pair mismatch

KW - DNA

KW - Donor-acceptor systems

KW - Hole transport

KW - Transient absorption spectroscopy

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JO - Journal of Photochemistry and Photobiology A: Chemistry

JF - Journal of Photochemistry and Photobiology A: Chemistry

SN - 1010-6030

ER -

Hole transport in DNA hairpins via base mismatches and strand crossings: Efficiency and dynamics

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Keywords

ASJC Scopus subject areas

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