Abstract
The efficiency and dynamics of hole transport via base mismatches and strand crossings have been determined for 10 DNA hairpins by means of femtosecond transient absorption spectroscopy. The hairpins possess a stilbenedicarboxamide hole donor and stilbenediether hole acceptor separated by seven base pairs. Hole transport occurs via an intra- or interstrand A3G4 diblock purine sequence that contains either a single base pair mismatch or strand crossing. Pyrimidine-pyrimidine mismatches (TT or CC) effectively block intrastrand hole transport; whereas purine-purine mismatches (AA or GG) permit efficient interstrand hole transport. Purine-to-purine intrastrand hole transport between adjacent matched base pairs is also moderately efficient (AG > AA > GG). Based upon these results AA mismatches are being employed in the design of three-way junctions for incorporation in prototype charge splitting and charge combining devices.
Original language | English (US) |
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Pages (from-to) | 160-164 |
Number of pages | 5 |
Journal | Journal of Photochemistry and Photobiology A: Chemistry |
Volume | 331 |
DOIs | |
State | Published - Dec 1 2016 |
Funding
This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Chemical Sciences, Geosciences, and Biosciences Division under Award DE-FG02-96ER14604 (F.D.L.) and the U.S. Office of Naval Research MURI grant no. N00014-11-1-0729 (M.R.W.).
Keywords
- Base-pair mismatch
- DNA
- Donor-acceptor systems
- Hole transport
- Transient absorption spectroscopy
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering
- General Physics and Astronomy