Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining

Kyung Hwa Jung; Kira L. Argenio; Daniel J. Jackson; Rachel L. Miller; Matthew S. Perzanowski; Andrew G. Rundle; Leonard B. Bacharier; William W. Busse; Robyn T. Cohen; Cynthia M. Visness; Michelle A. Gill; Rebecca S. Gruchalla; Gurjit K. Hershey; Rachel K. Kado; Michael G. Sherenian; Andrew H. Liu; Melanie M. Makhija; Dinesh K. Pillai; Katherine Rivera-Spoljaric; Peter J. Gergen; Matthew C. Altman; Megan T. Sandel; Christine A. Sorkness; Meyer Kattan; Stephanie Lovinsky-Desir

doi:10.1016/j.jaci.2024.06.020

Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining

Kyung Hwa Jung, Kira L. Argenio, Daniel J. Jackson, Rachel L. Miller, Matthew S. Perzanowski, Andrew G. Rundle, Leonard B. Bacharier, William W. Busse, Robyn T. Cohen, Cynthia M. Visness, Michelle A. Gill, Rebecca S. Gruchalla, Gurjit K. Hershey, Rachel K. Kado, Michael G. Sherenian, Andrew H. Liu, Melanie M. Makhija, Dinesh K. Pillai, Katherine Rivera-Spoljaric, Peter J. GergenMatthew C. Altman, Megan T. Sandel, Christine A. Sorkness, Meyer Kattan, Stephanie Lovinsky-Desir^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: The discriminatory and racist policy of historical redlining in the United States during the 1930s played a role in perpetuating contemporary environmental health disparities. Objective: Our objectives were to determine associations between home and school pollutant exposure (fine particulate matter [PM_2.5], NO₂) and respiratory outcomes (Composite Asthma Severity Index, lung function) among school-aged children with asthma and examine whether associations differed between children who resided and/or attended school in historically redlined compared to non-redlined neighborhoods. Methods: Children ages 6 to 17 with moderate-to-severe asthma (N = 240) from 9 US cities were included. Combined home and school exposure to PM_2.5 and NO₂ was calculated based on geospatially assessed monthly averaged outdoor pollutant concentrations. Repeated measures of Composite Asthma Severity Index and lung function were collected. Results: Overall, 37.5% of children resided and/or attended schools in historically redlined neighborhoods. Children in historically redlined neighborhoods had greater exposure to NO₂ (median: 15.4 vs 12.1 parts per billion) and closer distance to a highway (median: 0.86 vs 1.23 km), compared to those in non-redlined neighborhoods (P < .01). Overall, PM_2.5 was not associated with asthma severity or lung function. However, among children in redlined neighborhoods, higher PM_2.5 was associated with worse asthma severity (P < .005). No association was observed between pollutants and lung function or asthma severity among children in non-redlined neighborhoods (P > .005). Conclusions: Our findings highlight the significance of historical redlining and current environmental health disparities among school-aged children with asthma, specifically, the environmental injustice of PM_2.5 exposure and its associations with respiratory health.

Original language	English (US)
Pages (from-to)	1159-1168
Number of pages	10
Journal	Journal of Allergy and Clinical Immunology
Volume	154
Issue number	5
DOIs	https://doi.org/10.1016/j.jaci.2024.06.020
State	Published - Nov 2024

Funding

Supported by the National Institutes of Health (NIH-K01HL140216), Robert Wood Johnson Foundation, and Amos Medical Faculty Development Award. This project has been funded in whole or in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), National Center for Advancing Translational Sciences (NCATS), and Department of Health and Human Services under contract numbers 1UM1AI114271-01, UM2AI117870, 5UM1AI114271, NCATS/NIH UL1TR001079, NCATS/NIH 1UL1TR001430, NCATS/NIH UL1TR001873, NCATS/NIH UL1TR002345, UL1TRG01422, NIH/NCATS Colorado CTSA UL1 TR002535, NCATS/NIH UL1TR001876, and NIH/CTSA 5UL1TR001425-03.

Keywords

Home environment
asthma disparities
asthma severity
combined home and school exposure
composite asthma severity index
lung function
school environment
traffic-related air pollution

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jaci.2024.06.020

Cite this

Jung, K. H., Argenio, K. L., Jackson, D. J., Miller, R. L., Perzanowski, M. S., Rundle, A. G., Bacharier, L. B., Busse, W. W., Cohen, R. T., Visness, C. M., Gill, M. A., Gruchalla, R. S., Hershey, G. K., Kado, R. K., Sherenian, M. G., Liu, A. H., Makhija, M. M., Pillai, D. K., Rivera-Spoljaric, K., ... Lovinsky-Desir, S. (2024). Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining. Journal of Allergy and Clinical Immunology, 154(5), 1159-1168. https://doi.org/10.1016/j.jaci.2024.06.020

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title = "Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining",

abstract = "Background: The discriminatory and racist policy of historical redlining in the United States during the 1930s played a role in perpetuating contemporary environmental health disparities. Objective: Our objectives were to determine associations between home and school pollutant exposure (fine particulate matter [PM2.5], NO2) and respiratory outcomes (Composite Asthma Severity Index, lung function) among school-aged children with asthma and examine whether associations differed between children who resided and/or attended school in historically redlined compared to non-redlined neighborhoods. Methods: Children ages 6 to 17 with moderate-to-severe asthma (N = 240) from 9 US cities were included. Combined home and school exposure to PM2.5 and NO2 was calculated based on geospatially assessed monthly averaged outdoor pollutant concentrations. Repeated measures of Composite Asthma Severity Index and lung function were collected. Results: Overall, 37.5% of children resided and/or attended schools in historically redlined neighborhoods. Children in historically redlined neighborhoods had greater exposure to NO2 (median: 15.4 vs 12.1 parts per billion) and closer distance to a highway (median: 0.86 vs 1.23 km), compared to those in non-redlined neighborhoods (P < .01). Overall, PM2.5 was not associated with asthma severity or lung function. However, among children in redlined neighborhoods, higher PM2.5 was associated with worse asthma severity (P < .005). No association was observed between pollutants and lung function or asthma severity among children in non-redlined neighborhoods (P > .005). Conclusions: Our findings highlight the significance of historical redlining and current environmental health disparities among school-aged children with asthma, specifically, the environmental injustice of PM2.5 exposure and its associations with respiratory health.",

keywords = "Home environment, asthma disparities, asthma severity, combined home and school exposure, composite asthma severity index, lung function, school environment, traffic-related air pollution",

author = "Jung, {Kyung Hwa} and Argenio, {Kira L.} and Jackson, {Daniel J.} and Miller, {Rachel L.} and Perzanowski, {Matthew S.} and Rundle, {Andrew G.} and Bacharier, {Leonard B.} and Busse, {William W.} and Cohen, {Robyn T.} and Visness, {Cynthia M.} and Gill, {Michelle A.} and Gruchalla, {Rebecca S.} and Hershey, {Gurjit K.} and Kado, {Rachel K.} and Sherenian, {Michael G.} and Liu, {Andrew H.} and Makhija, {Melanie M.} and Pillai, {Dinesh K.} and Katherine Rivera-Spoljaric and Gergen, {Peter J.} and Altman, {Matthew C.} and Sandel, {Megan T.} and Sorkness, {Christine A.} and Meyer Kattan and Stephanie Lovinsky-Desir",

note = "Publisher Copyright: {\textcopyright} 2024 American Academy of Allergy, Asthma & Immunology",

year = "2024",

month = nov,

doi = "10.1016/j.jaci.2024.06.020",

language = "English (US)",

volume = "154",

pages = "1159--1168",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Elsevier Inc.",

number = "5",

}

Jung, KH, Argenio, KL, Jackson, DJ, Miller, RL, Perzanowski, MS, Rundle, AG, Bacharier, LB, Busse, WW, Cohen, RT, Visness, CM, Gill, MA, Gruchalla, RS, Hershey, GK, Kado, RK, Sherenian, MG, Liu, AH, Makhija, MM, Pillai, DK, Rivera-Spoljaric, K, Gergen, PJ, Altman, MC, Sandel, MT, Sorkness, CA, Kattan, M & Lovinsky-Desir, S 2024, 'Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining', Journal of Allergy and Clinical Immunology, vol. 154, no. 5, pp. 1159-1168. https://doi.org/10.1016/j.jaci.2024.06.020

TY - JOUR

T1 - Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining

AU - Jung, Kyung Hwa

AU - Argenio, Kira L.

AU - Jackson, Daniel J.

AU - Miller, Rachel L.

AU - Perzanowski, Matthew S.

AU - Rundle, Andrew G.

AU - Bacharier, Leonard B.

AU - Busse, William W.

AU - Cohen, Robyn T.

AU - Visness, Cynthia M.

AU - Gill, Michelle A.

AU - Gruchalla, Rebecca S.

AU - Hershey, Gurjit K.

AU - Kado, Rachel K.

AU - Sherenian, Michael G.

AU - Liu, Andrew H.

AU - Makhija, Melanie M.

AU - Pillai, Dinesh K.

AU - Rivera-Spoljaric, Katherine

AU - Gergen, Peter J.

AU - Altman, Matthew C.

AU - Sandel, Megan T.

AU - Sorkness, Christine A.

AU - Kattan, Meyer

AU - Lovinsky-Desir, Stephanie

PY - 2024/11

Y1 - 2024/11

N2 - Background: The discriminatory and racist policy of historical redlining in the United States during the 1930s played a role in perpetuating contemporary environmental health disparities. Objective: Our objectives were to determine associations between home and school pollutant exposure (fine particulate matter [PM2.5], NO2) and respiratory outcomes (Composite Asthma Severity Index, lung function) among school-aged children with asthma and examine whether associations differed between children who resided and/or attended school in historically redlined compared to non-redlined neighborhoods. Methods: Children ages 6 to 17 with moderate-to-severe asthma (N = 240) from 9 US cities were included. Combined home and school exposure to PM2.5 and NO2 was calculated based on geospatially assessed monthly averaged outdoor pollutant concentrations. Repeated measures of Composite Asthma Severity Index and lung function were collected. Results: Overall, 37.5% of children resided and/or attended schools in historically redlined neighborhoods. Children in historically redlined neighborhoods had greater exposure to NO2 (median: 15.4 vs 12.1 parts per billion) and closer distance to a highway (median: 0.86 vs 1.23 km), compared to those in non-redlined neighborhoods (P < .01). Overall, PM2.5 was not associated with asthma severity or lung function. However, among children in redlined neighborhoods, higher PM2.5 was associated with worse asthma severity (P < .005). No association was observed between pollutants and lung function or asthma severity among children in non-redlined neighborhoods (P > .005). Conclusions: Our findings highlight the significance of historical redlining and current environmental health disparities among school-aged children with asthma, specifically, the environmental injustice of PM2.5 exposure and its associations with respiratory health.

AB - Background: The discriminatory and racist policy of historical redlining in the United States during the 1930s played a role in perpetuating contemporary environmental health disparities. Objective: Our objectives were to determine associations between home and school pollutant exposure (fine particulate matter [PM2.5], NO2) and respiratory outcomes (Composite Asthma Severity Index, lung function) among school-aged children with asthma and examine whether associations differed between children who resided and/or attended school in historically redlined compared to non-redlined neighborhoods. Methods: Children ages 6 to 17 with moderate-to-severe asthma (N = 240) from 9 US cities were included. Combined home and school exposure to PM2.5 and NO2 was calculated based on geospatially assessed monthly averaged outdoor pollutant concentrations. Repeated measures of Composite Asthma Severity Index and lung function were collected. Results: Overall, 37.5% of children resided and/or attended schools in historically redlined neighborhoods. Children in historically redlined neighborhoods had greater exposure to NO2 (median: 15.4 vs 12.1 parts per billion) and closer distance to a highway (median: 0.86 vs 1.23 km), compared to those in non-redlined neighborhoods (P < .01). Overall, PM2.5 was not associated with asthma severity or lung function. However, among children in redlined neighborhoods, higher PM2.5 was associated with worse asthma severity (P < .005). No association was observed between pollutants and lung function or asthma severity among children in non-redlined neighborhoods (P > .005). Conclusions: Our findings highlight the significance of historical redlining and current environmental health disparities among school-aged children with asthma, specifically, the environmental injustice of PM2.5 exposure and its associations with respiratory health.

KW - Home environment

KW - asthma disparities

KW - asthma severity

KW - combined home and school exposure

KW - composite asthma severity index

KW - lung function

KW - school environment

KW - traffic-related air pollution

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U2 - 10.1016/j.jaci.2024.06.020

DO - 10.1016/j.jaci.2024.06.020

M3 - Article

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AN - SCOPUS:85200998523

SN - 0091-6749

VL - 154

SP - 1159

EP - 1168

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 5

ER -

Home and school pollutant exposure, respiratory outcomes, and influence of historical redlining

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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