Homeostatic roles of STING in cell proliferation and chromosomal instability

David R Gius, Yueming Zhu*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

In this issue of Cancer Research, Ranoa and colleagues report on the role of STING (stimulator of IFN genes, TMEM173) in regulating critical tumor cell-intrinsic functions including cell-cycle progression, chromosomal stability, and cellular response to therapeutic ionizing radiation. The authors used multiple methods including RNA expression profiling, molecular and biochemical techniques, cell biology, and reagents from genetically modified murine models to test their hypothesis that downregulating the STING pathway in cancer cells promotes cellular transformation through accumulation of chromosomal instability and premature progression of the cell cycle. Their findings demonstrate that STING is a tumor suppressor that inhibits cell proliferation by restricting entry to mitosis as well as protecting cells against aneuploidy. These findings significantly advance our understanding of the role of STING as a tumor gate keeper.

Original languageEnglish (US)
Pages (from-to)1295-1296
Number of pages2
JournalCancer Research
Volume79
Issue number7
DOIs
StatePublished - Jan 1 2019

Fingerprint

Chromosomal Instability
Cell Proliferation
Genes
Neoplasms
Cell Cycle
Aneuploidy
Ionizing Radiation
Mitosis
Cell Biology
Down-Regulation
RNA
Research

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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abstract = "In this issue of Cancer Research, Ranoa and colleagues report on the role of STING (stimulator of IFN genes, TMEM173) in regulating critical tumor cell-intrinsic functions including cell-cycle progression, chromosomal stability, and cellular response to therapeutic ionizing radiation. The authors used multiple methods including RNA expression profiling, molecular and biochemical techniques, cell biology, and reagents from genetically modified murine models to test their hypothesis that downregulating the STING pathway in cancer cells promotes cellular transformation through accumulation of chromosomal instability and premature progression of the cell cycle. Their findings demonstrate that STING is a tumor suppressor that inhibits cell proliferation by restricting entry to mitosis as well as protecting cells against aneuploidy. These findings significantly advance our understanding of the role of STING as a tumor gate keeper.",
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Homeostatic roles of STING in cell proliferation and chromosomal instability. / Gius, David R; Zhu, Yueming.

In: Cancer Research, Vol. 79, No. 7, 01.01.2019, p. 1295-1296.

Research output: Contribution to journalArticle

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