HOMOVANILLIC ACID AND 3‐METHOXY‐4‐ HYDROXYPHENYLETHYLENEGLYCOL PRODUCTION BY THE MONKEY SPINAL CORD

J. A. Kesslex; E. K. Gordon; J. L. Reid; I. J. Kopin

doi:10.1111/j.1471-4159.1976.tb06986.x

HOMOVANILLIC ACID AND 3‐METHOXY‐4‐ HYDROXYPHENYLETHYLENEGLYCOL PRODUCTION BY THE MONKEY SPINAL CORD

J. A. Kesslex^*, E. K. Gordon, J. L. Reid, I. J. Kopin

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The release of homovanillic acid (HVA) and 3‐methoxy‐4‐hydroxyphenylethyleneglycol (MHPG) into CSF by the monkey spinal cord was investigated with spinal subarachnoid perfusion of 20 rhesus monkeys. The preperfusion concentration of HVA in lumbar CSF was 365 ng/ml and in cisternal CSF was 365 ng/ml, while the concentrations of MHPG were 28.3 and 40.4 ng/ml respectively. HVA originating from the spinal cord appeared in the perfusate at a rate of 2.4 and MHPG at 1.4 ng/min. Treatment with probenecid either intraperitoneally or intrathecally did not alter the rate of release into CSF of these metabolites by the spinal cord but did significantly increase the rate of appearance in the cisterna magna of HVA originating from the brain. MHPG and HVA in lumbar CSF are therefore derived in part from spinal cord metabolism.

Original language	English (US)
Pages (from-to)	1057-1061
Number of pages	5
Journal	Journal of neurochemistry
Volume	26
Issue number	6
DOIs	https://doi.org/10.1111/j.1471-4159.1976.tb06986.x
State	Published - Jun 1976

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Biochemistry

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title = "HOMOVANILLIC ACID AND 3‐METHOXY‐4‐ HYDROXYPHENYLETHYLENEGLYCOL PRODUCTION BY THE MONKEY SPINAL CORD",

abstract = "The release of homovanillic acid (HVA) and 3‐methoxy‐4‐hydroxyphenylethyleneglycol (MHPG) into CSF by the monkey spinal cord was investigated with spinal subarachnoid perfusion of 20 rhesus monkeys. The preperfusion concentration of HVA in lumbar CSF was 365 ng/ml and in cisternal CSF was 365 ng/ml, while the concentrations of MHPG were 28.3 and 40.4 ng/ml respectively. HVA originating from the spinal cord appeared in the perfusate at a rate of 2.4 and MHPG at 1.4 ng/min. Treatment with probenecid either intraperitoneally or intrathecally did not alter the rate of release into CSF of these metabolites by the spinal cord but did significantly increase the rate of appearance in the cisterna magna of HVA originating from the brain. MHPG and HVA in lumbar CSF are therefore derived in part from spinal cord metabolism.",

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HOMOVANILLIC ACID AND 3‐METHOXY‐4‐ HYDROXYPHENYLETHYLENEGLYCOL PRODUCTION BY THE MONKEY SPINAL CORD

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