Homozygous inv(11)(q21q23) and MLL gene rearrangement in two patients with myeloid neoplasms

Guilin Tang*, Xinyan Lu, Sa A. Wang, Erin K. Roney, Liping Zhang, Shimin Hu, Gary Lu, L. Jeffrey Medeiros, Ankita Patel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Rearrangements of the MLL gene located at chromosome 11q23 are common chromosomal abnormalities associated with acute leukemias. In vast majority of cases with MLL gene rearrangements, only one chromosome 11 or a single MLL allele got involved. We report two very unusual cases of myeloid neoplasms with homozygous inv(11)(q21q23) and biallelic MLL rearrangement. Both patients, a 12-year old boy and a 29-year old woman, presented initially with T lymphoblastic leukemia/lymphoma (T-ALL), achieved complete remission with intensive chemotherapy, then recurred as acute myeloid leukemia in one patient and therapy-related myelodysplastic syndromes in the other patient, 24 and 15 months after initial T-ALL diagnosis, respectively. In both cases, biallelic MLL gene rearrangements were confirmed by fluorescence in situ hybridization. Mastermind like 2 gene was identified as MLL partner gene in one case. To our knowledge, homozygous inv(11)(q21q23) with two MLL genes rearrangement are extremely rare; it is likely a result of acquired uniparental disomy.

Original languageEnglish (US)
Pages (from-to)3196-3201
Number of pages6
JournalInternational Journal of Clinical and Experimental Pathology
Volume7
Issue number6
StatePublished - Jan 1 2014

Keywords

  • Acquired uniparental disomy
  • Homozygosity
  • Inv(11)(q21q23)
  • MLL-MAML2 fusion
  • Myeloid neoplasms
  • T lymphoblastic leukemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Fingerprint Dive into the research topics of 'Homozygous inv(11)(q21q23) and MLL gene rearrangement in two patients with myeloid neoplasms'. Together they form a unique fingerprint.

Cite this