Hormone exposure and its suppressive effect on risk of high-grade gliomas among patients with breast cancer

Carlos A. Lopez-Garcia, Victor Lopez-Rivera, Antonio Dono, Sergio Salazar-Marioni, Jorge E. Novo, Sunil A. Sheth, Leomar Y. Ballester*, Yoshua Esquenazi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Prior reports demonstrate the expression of estrogen and progesterone receptors in high-grade gliomas (HGGs), but the relationship between hormone receptor-positive disease and risk of HHGs in patients with breast cancer (BC) remains uncharacterized. Methods: Using the SEER 18 registries (2000–2017), we examined the temporal trend of the incidence of HGGs and BC. The standardized incidence ratio was calculated to assess the risk of subsequent HGG in BC patients. Results: During the study period, the incidence of BC and HGGs remained comparable for men and women. Among 976,134 patients with BC, we found a decreased incidence of HGGs in females, but not in males. Female BC patients with hormone receptor-positive disease were at a lower risk of developing glioblastoma and anaplastic astrocytoma. Conclusion: Our study findings allude to the protective role of hormone exposure in the development of HGGs, which may lead to the development of therapies targeting hormonal pathways.

Original languageEnglish (US)
Pages (from-to)200-203
Number of pages4
JournalJournal of Clinical Neuroscience
Volume94
DOIs
StatePublished - Dec 2021

Keywords

  • Anaplastic astrocytoma
  • Breast cancer
  • Glioblastoma
  • High-grade glioma
  • Hormone exposure
  • SEER

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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