Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon ALFA-2A

Jonathan J. Hubbard, Teresa Greenwell-Wild, Lisa Barrett, Jun Yang, Richard A. Lempicki, Sharon M. Wahl, David M. Asmuth, Robert L. Murphy, Richard B. Pollard, Shyam Kottilil*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r =-0.7; P <. 05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r 2 = 0.87, p =. 003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.

Original languageEnglish (US)
Pages (from-to)1443-1447
Number of pages5
JournalJournal of Infectious Diseases
Volume205
Issue number9
DOIs
StatePublished - May 1 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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