TY - JOUR
T1 - Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon ALFA-2A
AU - Hubbard, Jonathan J.
AU - Greenwell-Wild, Teresa
AU - Barrett, Lisa
AU - Yang, Jun
AU - Lempicki, Richard A.
AU - Wahl, Sharon M.
AU - Asmuth, David M.
AU - Murphy, Robert L.
AU - Pollard, Richard B.
AU - Kottilil, Shyam
N1 - Funding Information:
Financial support. This work was supported by the National Institutes of Health (NIH) (grant 1U01-AI068636 to the ACTG; grant 1U01-AI068634 to the ACTG Statistical and Data Analysis Center; grant 1U01-AI069471 to Northwestern University; grant 1U01-AI069432 to University of California, San Diego; grant 1U01-AI069484 to Duke University; Immunology Support Laboratory grant 201IC001 to University of California– Davis; and Immunology Support Laboratory grant 204IC006 to University of Pittsburgh, and the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Disease and the National Institute of Dental and Craniofacial Research). The participation of J. J. H. was made possible by the Clinical Research Training Program, a public-private partnership supported jointly by the NIH and Pfizer Inc (via a grant to the foundation for NIH from Pfizer). Potential conflicts of interest. All authors: No reported conflicts.
PY - 2012/5/1
Y1 - 2012/5/1
N2 - We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r =-0.7; P <. 05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r 2 = 0.87, p =. 003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.
AB - We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r =-0.7; P <. 05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r 2 = 0.87, p =. 003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.
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U2 - 10.1093/infdis/jis211
DO - 10.1093/infdis/jis211
M3 - Article
C2 - 22454462
AN - SCOPUS:84861543028
SN - 0022-1899
VL - 205
SP - 1443
EP - 1447
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 9
ER -
