Household food insecurity is associated with low interferongamma levels in pregnant Indian women

A. Vaidya, R. Bhosale, P. Sambarey, N. Suryavanshi, S. Young, V. Mave, S. Kanade, V. Kulkarni, P. Deshpande, U. Balasubramanian, J. Elf, N. Gupte, A. Gupta, J. S. Mathad*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

SETTING: Over 20% of tuberculosis (TB) cases during pregnancy occur in India. O B JE C T IVE : To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. DESIGN: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay. Logistic regression was used to identify factors associated with food insecurity. RESULT S : Of 538 women, 60 (11%) had household food insecurity, 47 (78%) of which were moderate or severe food insecure. After mitogen stimulation, moderate or severe food insecure women had a median IFN-γ concentration of 4.2 IU/ml (IQR 2.2-9.8) vs. 8.4 IU/ml (IQR 3.0-10) in women with no or mild food insecurity (P = 0.03). In multivariate analysis, higher IFN-γ concentrations were associated with human immunodeficiency virus infection (OR 1.3, 95%CI 0.51-2.1, P = 0.001), and inversely associated with moderate or severe food insecurity (OR -1.6, 95%CI -2.9 to -0.27, P = 0.02) and the number of adults in the household (OR -0.08, 95%CI-0.16 to-0.01, P=0.03). There was no association between food insecurity and IFN-γ response to Mycobacterium tuberculosis antigen. CONCLUS ION: Food insecurity in pregnancy is associated with low IFN-γ levels. There was no association between food insecurity and IFN-γ response to M. tuberculosis antigen, but our study was underpowered to detect this outcome.

Original languageEnglish (US)
Pages (from-to)797-803
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume21
Issue number7
DOIs
StatePublished - Jul 1 2017

Keywords

  • Interferon-gamma
  • Mitogen
  • Qgit
  • Tb antigen

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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    Vaidya, A., Bhosale, R., Sambarey, P., Suryavanshi, N., Young, S., Mave, V., Kanade, S., Kulkarni, V., Deshpande, P., Balasubramanian, U., Elf, J., Gupte, N., Gupta, A., & Mathad, J. S. (2017). Household food insecurity is associated with low interferongamma levels in pregnant Indian women. International Journal of Tuberculosis and Lung Disease, 21(7), 797-803. https://doi.org/10.5588/ijtld.16.0718