Household food insecurity is associated with low interferongamma levels in pregnant Indian women

A. Vaidya; R. Bhosale; P. Sambarey; N. Suryavanshi; S. Young; V. Mave; S. Kanade; V. Kulkarni; P. Deshpande; U. Balasubramanian; J. Elf; N. Gupte; A. Gupta; J. S. Mathad

doi:10.5588/ijtld.16.0718

Household food insecurity is associated with low interferongamma levels in pregnant Indian women

A. Vaidya, R. Bhosale, P. Sambarey, N. Suryavanshi, S. Young, V. Mave, S. Kanade, V. Kulkarni, P. Deshpande, U. Balasubramanian, J. Elf, N. Gupte, A. Gupta, J. S. Mathad^*

^*Corresponding author for this work

Anthropology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

SETTING: Over 20% of tuberculosis (TB) cases during pregnancy occur in India. O B JE C T IVE : To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. DESIGN: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay. Logistic regression was used to identify factors associated with food insecurity. RESULT S : Of 538 women, 60 (11%) had household food insecurity, 47 (78%) of which were moderate or severe food insecure. After mitogen stimulation, moderate or severe food insecure women had a median IFN-γ concentration of 4.2 IU/ml (IQR 2.2-9.8) vs. 8.4 IU/ml (IQR 3.0-10) in women with no or mild food insecurity (P = 0.03). In multivariate analysis, higher IFN-γ concentrations were associated with human immunodeficiency virus infection (OR 1.3, 95%CI 0.51-2.1, P = 0.001), and inversely associated with moderate or severe food insecurity (OR -1.6, 95%CI -2.9 to -0.27, P = 0.02) and the number of adults in the household (OR -0.08, 95%CI-0.16 to-0.01, P=0.03). There was no association between food insecurity and IFN-γ response to Mycobacterium tuberculosis antigen. CONCLUS ION: Food insecurity in pregnancy is associated with low IFN-γ levels. There was no association between food insecurity and IFN-γ response to M. tuberculosis antigen, but our study was underpowered to detect this outcome.

Original language	English (US)
Pages (from-to)	797-803
Number of pages	7
Journal	International Journal of Tuberculosis and Lung Disease
Volume	21
Issue number	7
DOIs	https://doi.org/10.5588/ijtld.16.0718
State	Published - Jul 1 2017

Funding

This study was supported by the Johns Hopkins Baltimore- Washington-India Clinical Trials Unit (Pune, India; BWI CTU) (UM1AI069465); US National Institutes of Health (NIH), the National Institute for Child Health and Human Development (R01HD081929), the Fogarty International Center NIH Program of International Training Grants in Epidemiology Related to AIDS (Bethesda, MD, USA; D43TW000010); grants from the Gilead Foundation (Okehampton, UK), the Ujala Foundation (Newtown Square, PA, USA), and the Wyncote Foundation (Philadelphia, PA, USA). In addition, JSM was supported by a training grant from the NIH National Institute of Allergy and Infectious Diseases (T32 AI007613), and the Weill Cornell Clinical and Translational Science Center, New York, NY, USA (KL2 TR00458). AVV was supported by the Infectious Diseases Society of America Medical Scholars program (2015).

Keywords

Interferon-gamma
Mitogen
Qgit
Tb antigen

ASJC Scopus subject areas

Infectious Diseases
Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.5588/ijtld.16.0718

Cite this

Vaidya, A., Bhosale, R., Sambarey, P., Suryavanshi, N., Young, S., Mave, V., Kanade, S., Kulkarni, V., Deshpande, P., Balasubramanian, U., Elf, J., Gupte, N., Gupta, A., & Mathad, J. S. (2017). Household food insecurity is associated with low interferongamma levels in pregnant Indian women. International Journal of Tuberculosis and Lung Disease, 21(7), 797-803. https://doi.org/10.5588/ijtld.16.0718

@article{27e595d72cfc449789c972e20ddeeef4,

title = "Household food insecurity is associated with low interferongamma levels in pregnant Indian women",

abstract = "SETTING: Over 20% of tuberculosis (TB) cases during pregnancy occur in India. O B JE C T IVE : To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. DESIGN: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay. Logistic regression was used to identify factors associated with food insecurity. RESULT S : Of 538 women, 60 (11%) had household food insecurity, 47 (78%) of which were moderate or severe food insecure. After mitogen stimulation, moderate or severe food insecure women had a median IFN-γ concentration of 4.2 IU/ml (IQR 2.2-9.8) vs. 8.4 IU/ml (IQR 3.0-10) in women with no or mild food insecurity (P = 0.03). In multivariate analysis, higher IFN-γ concentrations were associated with human immunodeficiency virus infection (OR 1.3, 95%CI 0.51-2.1, P = 0.001), and inversely associated with moderate or severe food insecurity (OR -1.6, 95%CI -2.9 to -0.27, P = 0.02) and the number of adults in the household (OR -0.08, 95%CI-0.16 to-0.01, P=0.03). There was no association between food insecurity and IFN-γ response to Mycobacterium tuberculosis antigen. CONCLUS ION: Food insecurity in pregnancy is associated with low IFN-γ levels. There was no association between food insecurity and IFN-γ response to M. tuberculosis antigen, but our study was underpowered to detect this outcome.",

keywords = "Interferon-gamma, Mitogen, Qgit, Tb antigen",

author = "A. Vaidya and R. Bhosale and P. Sambarey and N. Suryavanshi and S. Young and V. Mave and S. Kanade and V. Kulkarni and P. Deshpande and U. Balasubramanian and J. Elf and N. Gupte and A. Gupta and Mathad, {J. S.}",

note = "Publisher Copyright: {\textcopyright}2017 The Union.",

year = "2017",

month = jul,

day = "1",

doi = "10.5588/ijtld.16.0718",

language = "English (US)",

volume = "21",

pages = "797--803",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union against Tubercul. and Lung Dis.",

number = "7",

}

Vaidya, A, Bhosale, R, Sambarey, P, Suryavanshi, N, Young, S, Mave, V, Kanade, S, Kulkarni, V, Deshpande, P, Balasubramanian, U, Elf, J, Gupte, N, Gupta, A & Mathad, JS 2017, 'Household food insecurity is associated with low interferongamma levels in pregnant Indian women', International Journal of Tuberculosis and Lung Disease, vol. 21, no. 7, pp. 797-803. https://doi.org/10.5588/ijtld.16.0718

TY - JOUR

T1 - Household food insecurity is associated with low interferongamma levels in pregnant Indian women

AU - Vaidya, A.

AU - Bhosale, R.

AU - Sambarey, P.

AU - Suryavanshi, N.

AU - Young, S.

AU - Mave, V.

AU - Kanade, S.

AU - Kulkarni, V.

AU - Deshpande, P.

AU - Balasubramanian, U.

AU - Elf, J.

AU - Gupte, N.

AU - Gupta, A.

AU - Mathad, J. S.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - SETTING: Over 20% of tuberculosis (TB) cases during pregnancy occur in India. O B JE C T IVE : To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. DESIGN: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay. Logistic regression was used to identify factors associated with food insecurity. RESULT S : Of 538 women, 60 (11%) had household food insecurity, 47 (78%) of which were moderate or severe food insecure. After mitogen stimulation, moderate or severe food insecure women had a median IFN-γ concentration of 4.2 IU/ml (IQR 2.2-9.8) vs. 8.4 IU/ml (IQR 3.0-10) in women with no or mild food insecurity (P = 0.03). In multivariate analysis, higher IFN-γ concentrations were associated with human immunodeficiency virus infection (OR 1.3, 95%CI 0.51-2.1, P = 0.001), and inversely associated with moderate or severe food insecurity (OR -1.6, 95%CI -2.9 to -0.27, P = 0.02) and the number of adults in the household (OR -0.08, 95%CI-0.16 to-0.01, P=0.03). There was no association between food insecurity and IFN-γ response to Mycobacterium tuberculosis antigen. CONCLUS ION: Food insecurity in pregnancy is associated with low IFN-γ levels. There was no association between food insecurity and IFN-γ response to M. tuberculosis antigen, but our study was underpowered to detect this outcome.

AB - SETTING: Over 20% of tuberculosis (TB) cases during pregnancy occur in India. O B JE C T IVE : To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. DESIGN: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay. Logistic regression was used to identify factors associated with food insecurity. RESULT S : Of 538 women, 60 (11%) had household food insecurity, 47 (78%) of which were moderate or severe food insecure. After mitogen stimulation, moderate or severe food insecure women had a median IFN-γ concentration of 4.2 IU/ml (IQR 2.2-9.8) vs. 8.4 IU/ml (IQR 3.0-10) in women with no or mild food insecurity (P = 0.03). In multivariate analysis, higher IFN-γ concentrations were associated with human immunodeficiency virus infection (OR 1.3, 95%CI 0.51-2.1, P = 0.001), and inversely associated with moderate or severe food insecurity (OR -1.6, 95%CI -2.9 to -0.27, P = 0.02) and the number of adults in the household (OR -0.08, 95%CI-0.16 to-0.01, P=0.03). There was no association between food insecurity and IFN-γ response to Mycobacterium tuberculosis antigen. CONCLUS ION: Food insecurity in pregnancy is associated with low IFN-γ levels. There was no association between food insecurity and IFN-γ response to M. tuberculosis antigen, but our study was underpowered to detect this outcome.

KW - Interferon-gamma

KW - Mitogen

KW - Qgit

KW - Tb antigen

UR - http://www.scopus.com/inward/record.url?scp=85021149824&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021149824&partnerID=8YFLogxK

U2 - 10.5588/ijtld.16.0718

DO - 10.5588/ijtld.16.0718

M3 - Article

C2 - 28633705

AN - SCOPUS:85021149824

SN - 1027-3719

VL - 21

SP - 797

EP - 803

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 7

ER -

Household food insecurity is associated with low interferongamma levels in pregnant Indian women

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this