How and why nanoparticle's curvature regulates the apparent pKa of the coating ligands

Dawei Wang; Rikkert J. Nap; István Lagzi; Bartlomiej Kowalczyk; Shuangbing Han; Bartosz A. Grzybowski; Igal Szleifer

doi:10.1021/ja108154a

How and why nanoparticle's curvature regulates the apparent pK_a of the coating ligands

Dawei Wang, Rikkert J. Nap, István Lagzi, Bartlomiej Kowalczyk, Shuangbing Han, Bartosz A. Grzybowski, Igal Szleifer

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

203 Scopus citations

Abstract

Dissociation of ionizable ligands immobilized on nanopaticles (NPs) depends on and can be regulated by the curvature of these particles as well as the size and the concentration of counterions. The apparent acid dissociation constant (pK_a) of the NP-immobilized ligands lies between that of free ligands and ligands self-assembled on a flat surface. This phenomenon is explicitly rationalized by a theoretical model that accounts fully for the molecular details (size, shape, conformation, and charge distribution) of both the NPs and the counterions.

Original language	English (US)
Pages (from-to)	2192-2197
Number of pages	6
Journal	Journal of the American Chemical Society
Volume	133
Issue number	7
DOIs	https://doi.org/10.1021/ja108154a
State	Published - Feb 23 2011

ASJC Scopus subject areas

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

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AU - Han, Shuangbing

AU - Grzybowski, Bartosz A.

AU - Szleifer, Igal

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How and why nanoparticle's curvature regulates the apparent pK_a of the coating ligands

Abstract

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