TY - CHAP
T1 - How creative elements help the recovery of networks after crisis
T2 - Lessons from biology
AU - Mihalik, Ágoston
AU - Kaposi, Ambrus S.
AU - Kovács, István A.
AU - Nánási, Tibor
AU - Palotai, Robin
AU - Rák, Ádám
AU - Szalay-Beko, Máté S.
AU - Csermely, Peter
PY - 2012/1/1
Y1 - 2012/1/1
N2 - In the middle of a world economic crisis, studies of biological crisis-survival strategies, which have proven their efficiency over a billion years of evolution, may provide novel ideas and solutions. In this chapter, we summarize our knowledge and the latest results which show that the “crisis of cells,” called stress in biology, and its extreme form, programmed cell death (also known as apoptosis), induce a decrease in the inter-modular contacts of protein–protein interaction networks of yeast and human cells, respectively. Moreover, programmed cell death leads to the decomposition of several key modules of human cells. This network disintegration fits well with the general scheme of network topological phase transitions upon a decrease of resources (and/or an increase of perturbations, stress). The modular disassembly resembles changes to social networks in crisis-like situations. Thus, the re-association of cellular networks after stress and the necessity of mobile, intermodular elements (“creative elements”) for this process of “modular evolution” may give us adaptable schemes for crisis-survival strategies, proving the old observation that a crisis is not a disaster but a challenge providing a chance for development. How can biological networks help our coping with crisis situations and our understanding of social networks? From the second half of the twentieth century, the increasing complexity and the information-richness of our everyday life have got closer and closer to the limits of the information handling capacity of our logical, left-hemisphere brain. The Western civilization has been increasingly using (and actually, over-using) logical thinking from the very beginning and, especially, from the Enlightenment of the eighteenth century, signaling the birth of modern scientific thinking. Our schools socialize us and our children to accommodate a conceptual framework, which makes the logical assessment of the changing situations a Pavlovian conditioning of modern times.
AB - In the middle of a world economic crisis, studies of biological crisis-survival strategies, which have proven their efficiency over a billion years of evolution, may provide novel ideas and solutions. In this chapter, we summarize our knowledge and the latest results which show that the “crisis of cells,” called stress in biology, and its extreme form, programmed cell death (also known as apoptosis), induce a decrease in the inter-modular contacts of protein–protein interaction networks of yeast and human cells, respectively. Moreover, programmed cell death leads to the decomposition of several key modules of human cells. This network disintegration fits well with the general scheme of network topological phase transitions upon a decrease of resources (and/or an increase of perturbations, stress). The modular disassembly resembles changes to social networks in crisis-like situations. Thus, the re-association of cellular networks after stress and the necessity of mobile, intermodular elements (“creative elements”) for this process of “modular evolution” may give us adaptable schemes for crisis-survival strategies, proving the old observation that a crisis is not a disaster but a challenge providing a chance for development. How can biological networks help our coping with crisis situations and our understanding of social networks? From the second half of the twentieth century, the increasing complexity and the information-richness of our everyday life have got closer and closer to the limits of the information handling capacity of our logical, left-hemisphere brain. The Western civilization has been increasingly using (and actually, over-using) logical thinking from the very beginning and, especially, from the Enlightenment of the eighteenth century, signaling the birth of modern scientific thinking. Our schools socialize us and our children to accommodate a conceptual framework, which makes the logical assessment of the changing situations a Pavlovian conditioning of modern times.
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U2 - 10.1017/CBO9780511842481.010
DO - 10.1017/CBO9780511842481.010
M3 - Chapter
AN - SCOPUS:84923525534
SN - 9781107009837
SP - 179
EP - 188
BT - Networks in Social Policy Problems
PB - Cambridge University Press
ER -