How does cro repressor recognize its DNA target sites?

B. W. Matthews*, D. H. Ohlendorf, W. F. Anderson, R. G. Fisher, Y. Takeda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The structure of the cro repressor from bacteriophage λ suggests that a pair of α-helices of this gene-regulatory protein bind to its sequence-specific sites on the DNA. These protein α-helices lie within successive major grooves of the DNA, and amino acid side chains make multiple hydrogen bonds with the accessible parts of the DNA base pairs. Each α-helix is part of a common two-helical DNA-binding fold that apparently occurs in many proteins that regulate gene expression.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalTrends in Biochemical Sciences
Issue number1
StatePublished - Jan 1983

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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