How does increased cardiac output increase shunt in pulmonary edema?

P. H. Breen, P. T. Schumacker, G. Hedenstierna, J. Ali, P. D. Wagner, L. D. Wood

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


In pulmonary edema, the relationship between cardiac output (Q̇T) and shunt (Q̇S/Q̇T) may be due to a diffusion barrier for O2 transfer (incomplete alveolar-capillary equilibration) or to redistribution of increased pulmonary blood flow toward edematous units. We compared transfer of O2 and multiple inert gases in the left (LLL) and right (RLL) lower lobes and in the whole lungs of eight dogs having oleic acid edema in LLL. When mean Q̇T was increased from 3.0 to 5.5 l.min-1 during O2 ventilation, relative perfusion of LLL did not increase but Q̇S/Q̇T increased because LLL shunt increased from 56 to 78%. We conclude that increased pulmonary blood flow is not redistributed toward edematous regions, but we cannot exclude such redistribution within LLL and other slightly edematous lobes. In LLL, inert gas shunt and O2 shunt were not systematically different during O2 ventilation, and lobar venous P(O2) measured during air ventilation was not different from that predicted by inert gas transfer. We conclude that diffusion limitation for O2 does not contribute to Q̇S/Q̇T or to the increase in Q̇S/Q̇T when QT increases. Conceivably, increased Q̇T increased QΣ/Q by increasing edema or hematocrit in edematous regions.

Original languageEnglish (US)
Pages (from-to)1273-1280
Number of pages8
JournalUnknown Journal
Issue number5
StatePublished - 1982

ASJC Scopus subject areas

  • Physiology
  • Endocrinology


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