How I treat elderly patients with myeloma

Jayesh Mehta*, Michele Cavo, Seema Singhal

*Corresponding author for this work

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

The clinical approach to older patients with myeloma has to be modified to take into account comorbidities and the likelihood of higher treatment-related toxicity. Individualization of management and adequate supportive therapy are important to obtain the best response while minimizing adverse effects. Corticosteroids, novel agents, conventional cytotoxic agents, and high-dose chemotherapy with autotransplantation (modalities used in younger patients) are also used in older patients, although the elderly undergo transplantation less frequently. The sequential use of active agents singly and in different combinations has improved response rates and survival of all patients with myeloma, including the elderly.

Original languageEnglish (US)
Pages (from-to)2215-2223
Number of pages9
JournalBlood
Volume116
Issue number13
DOIs
StatePublished - Sep 30 2010

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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