TY - JOUR
T1 - How I treat patients with inherited bleeding disorders who need anticoagulant therapy
AU - Martin, Karlyn
AU - Key, Nigel S.
N1 - Publisher Copyright:
© 2016 by The American Society of Hematology.
PY - 2016/7/14
Y1 - 2016/7/14
N2 - Situations that ordinarily necessitate consideration of anticoagulation, such as arterial and venous thrombotic events and prevention of stroke in atrial fibrillation, become challenging in patients with inherited bleeding disorders such as hemophilia A, hemophilia B, and von Willebrand disease. There are no evidence-based guidelines to direct therapy in these patients, and management strategies that incorporate anticoagulation must weigh a treatment that carries a risk of hemorrhage in a patient who is already at heightened risk against the potential consequences of not treating the thrombotic event. In this paper, we review atherothrombotic disease, venous thrombotic disease, and atrial fibrillation in patients with inherited bleeding disorders, and discuss strategies for using anticoagulants in this population using cases to illustrate these considerations.
AB - Situations that ordinarily necessitate consideration of anticoagulation, such as arterial and venous thrombotic events and prevention of stroke in atrial fibrillation, become challenging in patients with inherited bleeding disorders such as hemophilia A, hemophilia B, and von Willebrand disease. There are no evidence-based guidelines to direct therapy in these patients, and management strategies that incorporate anticoagulation must weigh a treatment that carries a risk of hemorrhage in a patient who is already at heightened risk against the potential consequences of not treating the thrombotic event. In this paper, we review atherothrombotic disease, venous thrombotic disease, and atrial fibrillation in patients with inherited bleeding disorders, and discuss strategies for using anticoagulants in this population using cases to illustrate these considerations.
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U2 - 10.1182/blood-2015-12-635094
DO - 10.1182/blood-2015-12-635094
M3 - Article
C2 - 27106121
AN - SCOPUS:84978379733
SN - 0006-4971
VL - 128
SP - 178
EP - 184
JO - Blood
JF - Blood
IS - 2
ER -