How lung injury and therapeutic oxygen could alter white matter development

Robert W. Dettman*, Maria L.V. Dizon

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Developmental brain injury describes a spectrum of neurological pathologies resulting from either antenatal or perinatal injury. This includes both cognitive and motor defects that affect patients for their entire lives. Developmental brain injury can be caused by a spectrum of conditions including stroke, perinatal hypoxia-ischemia, and intracranial hemorrhage. Additional risk factors have been identified including very low birth weight, mechanical ventilation, and oxygen (O2) supplementation. In fact, infants with bronchopulmonary dysplasia, an inflammatory disease associated with disrupted lung development, have been shown to have decreased cerebral white matter and decreased intracranial volumes. Thus, there appears to be a developmental link between the lung, O2, and the brain that leads to proper myelination. Here, we will discuss what is currently known about the link between O2 and myelination and how scientists are exploring mechanisms through which supplemental O2 and/or lung injury can affect brain development. Consideration of a link between the diseased lung and developing brain will allow clinicians to fine tune their approaches in managing preterm lung disease in order to optimize brain health.

Original languageEnglish (US)
JournalJournal of Neuroscience Research
DOIs
StateAccepted/In press - 2021

Keywords

  • White matter Injury
  • animal models
  • neurodevelopmental impairment
  • oxygen
  • prematurity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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