How molecular testing can help (and hurt) in the workup of gliomas

Kenneth Clark, Zoya Voronovich, Craig Horbinski*

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Advances in genetics research have greatly expanded our ability to accurately diagnose gliomas and provide more useful prognostic information. Herein specific examples are used to show how highyield targets such as EGFR, 1p/19q, IDH1/2, MGMT, and BRAF can expand the power of the surgical neuropathologist. To avoid errors, however, the significance and controversies associated with each test must be thoroughly understood.

Original languageEnglish (US)
Pages (from-to)275-288
Number of pages14
JournalAmerican journal of clinical pathology
Volume139
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • 1p/19q
  • BRAF
  • EGFR
  • Glioma
  • IDH1/2
  • MGMT

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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