How patients with Parkinson's disease retrieve and manage cognitive event knowledge

Tiziana Zalla*, Angela Sirigu, Bernard Pillon, Bruno Dubois, Yves Agid, Jordan Grafman

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Several studies have pointed out that basal ganglia are involved in adaptive control of action at both motor and cognitive level. This study aimed to investigate how basal ganglia retrieve and manage script event knowledge required in planning behavior. Script event knowledge was investigated in patients with Parkinson's Disease using three kinds of activity that differed in familiarity. Unlike patients with prefrontal lesions, patients with Parkinson's Disease were able to order events in a typical sequence and obeyed the boundaries and hierarchies between events. In contrast, patients with Parkinson's Disease were impaired in evaluating how important each script event was within the context of goal-oriented planning activity. Our findings indicate that the prefrontal cortex and the basal ganglia are differentially involved in planning. The role of the basal ganglia might consist in providing a feedback about the goodness of each action while building up meaningful sequences of events during learning.

Original languageEnglish (US)
Pages (from-to)163-179
Number of pages17
JournalCortex
Volume36
Issue number2
DOIs
StatePublished - Jan 1 2000

Fingerprint

Basal Ganglia
Parkinson Disease
Prefrontal Cortex
Learning

Keywords

  • Basal ganglia
  • Frontal lobe
  • Motivation
  • Reward
  • Scripts

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Cite this

Zalla, Tiziana ; Sirigu, Angela ; Pillon, Bernard ; Dubois, Bruno ; Agid, Yves ; Grafman, Jordan. / How patients with Parkinson's disease retrieve and manage cognitive event knowledge. In: Cortex. 2000 ; Vol. 36, No. 2. pp. 163-179.
@article{c4b06e63fce3475fa755aca069329b2a,
title = "How patients with Parkinson's disease retrieve and manage cognitive event knowledge",
abstract = "Several studies have pointed out that basal ganglia are involved in adaptive control of action at both motor and cognitive level. This study aimed to investigate how basal ganglia retrieve and manage script event knowledge required in planning behavior. Script event knowledge was investigated in patients with Parkinson's Disease using three kinds of activity that differed in familiarity. Unlike patients with prefrontal lesions, patients with Parkinson's Disease were able to order events in a typical sequence and obeyed the boundaries and hierarchies between events. In contrast, patients with Parkinson's Disease were impaired in evaluating how important each script event was within the context of goal-oriented planning activity. Our findings indicate that the prefrontal cortex and the basal ganglia are differentially involved in planning. The role of the basal ganglia might consist in providing a feedback about the goodness of each action while building up meaningful sequences of events during learning.",
keywords = "Basal ganglia, Frontal lobe, Motivation, Reward, Scripts",
author = "Tiziana Zalla and Angela Sirigu and Bernard Pillon and Bruno Dubois and Yves Agid and Jordan Grafman",
year = "2000",
month = "1",
day = "1",
doi = "10.1016/S0010-9452(08)70522-7",
language = "English (US)",
volume = "36",
pages = "163--179",
journal = "Cortex",
issn = "0010-9452",
publisher = "Masson SpA",
number = "2",

}

How patients with Parkinson's disease retrieve and manage cognitive event knowledge. / Zalla, Tiziana; Sirigu, Angela; Pillon, Bernard; Dubois, Bruno; Agid, Yves; Grafman, Jordan.

In: Cortex, Vol. 36, No. 2, 01.01.2000, p. 163-179.

Research output: Contribution to journalArticle

TY - JOUR

T1 - How patients with Parkinson's disease retrieve and manage cognitive event knowledge

AU - Zalla, Tiziana

AU - Sirigu, Angela

AU - Pillon, Bernard

AU - Dubois, Bruno

AU - Agid, Yves

AU - Grafman, Jordan

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Several studies have pointed out that basal ganglia are involved in adaptive control of action at both motor and cognitive level. This study aimed to investigate how basal ganglia retrieve and manage script event knowledge required in planning behavior. Script event knowledge was investigated in patients with Parkinson's Disease using three kinds of activity that differed in familiarity. Unlike patients with prefrontal lesions, patients with Parkinson's Disease were able to order events in a typical sequence and obeyed the boundaries and hierarchies between events. In contrast, patients with Parkinson's Disease were impaired in evaluating how important each script event was within the context of goal-oriented planning activity. Our findings indicate that the prefrontal cortex and the basal ganglia are differentially involved in planning. The role of the basal ganglia might consist in providing a feedback about the goodness of each action while building up meaningful sequences of events during learning.

AB - Several studies have pointed out that basal ganglia are involved in adaptive control of action at both motor and cognitive level. This study aimed to investigate how basal ganglia retrieve and manage script event knowledge required in planning behavior. Script event knowledge was investigated in patients with Parkinson's Disease using three kinds of activity that differed in familiarity. Unlike patients with prefrontal lesions, patients with Parkinson's Disease were able to order events in a typical sequence and obeyed the boundaries and hierarchies between events. In contrast, patients with Parkinson's Disease were impaired in evaluating how important each script event was within the context of goal-oriented planning activity. Our findings indicate that the prefrontal cortex and the basal ganglia are differentially involved in planning. The role of the basal ganglia might consist in providing a feedback about the goodness of each action while building up meaningful sequences of events during learning.

KW - Basal ganglia

KW - Frontal lobe

KW - Motivation

KW - Reward

KW - Scripts

UR - http://www.scopus.com/inward/record.url?scp=0034048365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034048365&partnerID=8YFLogxK

U2 - 10.1016/S0010-9452(08)70522-7

DO - 10.1016/S0010-9452(08)70522-7

M3 - Article

VL - 36

SP - 163

EP - 179

JO - Cortex

JF - Cortex

SN - 0010-9452

IS - 2

ER -