TY - JOUR
T1 - How prenatal exposures shape the infant brain
T2 - Insights from infant neuroimaging studies
AU - Dufford, Alexander J.
AU - Spann, Marisa
AU - Scheinost, Dustin
N1 - Funding Information:
This work was supported by the National Institute of Mental Health (grant Nos. MH093677, MH117983, and MH018268). AJD is supported by T32MH18268. We thank Corey Horien, Max Rolison, Silvia Gini, and Link Tejavibulya for their helpful comments on initial drafts of this work.
Funding Information:
This work was supported by the National Institute of Mental Health (grant Nos. MH093677 , MH117983 , and MH018268 ). AJD is supported by T32MH18268 . We thank Corey Horien, Max Rolison, Silvia Gini, and Link Tejavibulya for their helpful comments on initial drafts of this work.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12
Y1 - 2021/12
N2 - Brain development during the prenatal period is rapid and unparalleled by any other time during development. Biological systems undergoing rapid development are at higher risk for disorganizing influences. Therefore, certain prenatal exposures impact brain development, increasing risk for negative neurodevelopmental outcome. While prenatal exposures have been associated with cognitive and behavioral outcomes later in life, the underlying macroscopic brain pathways remain unclear. Here, we review magnetic resonance imaging (MRI) studies investigating the association between prenatal exposures and infant brain development focusing on prenatal exposures via maternal physical health factors, maternal mental health factors, and maternal drug and medication use. Further, we discuss the need for studies to consider multiple prenatal exposures in parallel and suggest future directions for this body of research.
AB - Brain development during the prenatal period is rapid and unparalleled by any other time during development. Biological systems undergoing rapid development are at higher risk for disorganizing influences. Therefore, certain prenatal exposures impact brain development, increasing risk for negative neurodevelopmental outcome. While prenatal exposures have been associated with cognitive and behavioral outcomes later in life, the underlying macroscopic brain pathways remain unclear. Here, we review magnetic resonance imaging (MRI) studies investigating the association between prenatal exposures and infant brain development focusing on prenatal exposures via maternal physical health factors, maternal mental health factors, and maternal drug and medication use. Further, we discuss the need for studies to consider multiple prenatal exposures in parallel and suggest future directions for this body of research.
KW - Brain development
KW - Environmental
KW - Perinatal
KW - Pregnancy
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U2 - 10.1016/j.neubiorev.2021.09.017
DO - 10.1016/j.neubiorev.2021.09.017
M3 - Review article
C2 - 34536461
AN - SCOPUS:85115038485
SN - 0149-7634
VL - 131
SP - 47
EP - 58
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -
