How to design multi-target drugs: Target search options in cellular networks

Tamás Korcsmáros, Máté S. Szalay, Csaba Böde, István A. Kovács, Péter Csermelyt

Research output: Contribution to journalReview article

130 Scopus citations

Abstract

Despite improved rational drug design and a remarkable progress in genomic, proteomic and high-throughput screening methods, the number of novel, single-target drugs has fallen far behind expectations during the past decade. Multi-target drugs multiply the number of pharmacologically relevant target molecules by introducing a set of indirect, network-dependent effects. Parallel with this, the low-affinity binding of multi-target drugs eases the constraints of druggability and significantly increases the size of the druggable proteome. These effects tremendously expand the number of potential drug targets and introduce novel classes of multi-target drugs with smaller side effects and toxicity. Here, the authors review the recent progress in this field, compare possible network attack strqegies and propose several methods to find target-sets for multi-target drugs.

Original languageEnglish (US)
Pages (from-to)799-808
Number of pages10
JournalExpert Opinion on Drug Discovery
Volume2
Issue number6
DOIs
StatePublished - Jun 1 2007

Keywords

  • Antibiotics
  • Disordered proteins
  • Drug targets
  • Fungicides
  • Genomics
  • Multi-target drugs
  • Network damage
  • Networks
  • Pesticides
  • Phosphorylation
  • Protein kinases
  • Proteomics
  • Signaling networks

ASJC Scopus subject areas

  • Drug Discovery

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