How Vitamin D Works on Bone

Tomohiko Yoshida, Paula H. Stern*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Vitamin D is important for the normal development and maintenance of bone. The elucidation of the vitamin D activation pathway and the cloning of the vitamin D receptor have advanced our understanding of the actions of vitamin D on bone. The preponderance of evidence indicates that 1,25(OH)2D3 enhances bone mineralization through its effects to promote calcium and phosphate absorption. Although 1,25(OH)2D3 stimulates bone resorption in vitro, treatment in vivo can prevent bone loss and fracture through several potential mechanisms. The development of vitamin D analogues has provided new therapeutic options for increasing bone mineral density and reducing fractures.

Original languageEnglish (US)
Pages (from-to)557-569
Number of pages13
JournalEndocrinology and Metabolism Clinics of North America
Issue number3
StatePublished - Sep 2012


  • Analogues
  • Bone resorption
  • Fracture
  • Mineralization
  • Osteomalacia
  • Rickets
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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