HSC Fate Is Tethered to Mitochondria

Lauren P. Diebold, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

Mitochondria play important roles in homeostasis of hematopoietic stem cells (HSCs), which exhibit clonal heterogeneity in their lymphoid and myeloid production. Recently in Nature, Luchsinger et al. (2016) showed that mitochondria-ER tethering maintains lymphoid-biased HSCs through calcium-dependent NFAT signaling, providing molecular insights into the basis of HSC heterogeneity.

Original languageEnglish (US)
Pages (from-to)303-304
Number of pages2
JournalCell Stem Cell
Volume18
Issue number3
DOIs
StatePublished - Mar 3 2016

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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