Hsp-27 is not expressed and has no prognostic significance in rectal adenocarcinoma

F. K. Storm*, D. M. Mahvi, K. W. Gilchrist

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This investigation involves the expression of heat shock protein 27 (hsp-27) in rectal carcinoma. Hsp-27 protein expression is correlated with prognosis in patients with node-negative breast cancer as well as malignant fibrous histiocytoma. It may be an important predictor of outcome in other high risk tumors which could influence the use of adjuvant therapy. Archival primary tumor specimens of 44 patients with previously untreated surgically resected adenocarcinoma of the rectum and 5-year minimum follow-up were evaluated by immunohistochemistry for hsp-27 expression. Patients were stratified by age, gender, degree of invasion and differentiation, lymph node status, local recurrence and survival. No tumor in this investigation expressed this protein to any significant degree. Hsp-27, therefore, has no value for predicting the outcome of patients with rectal carcinoma.

Original languageEnglish (US)
Pages (from-to)146-148
Number of pages3
JournalRegional Cancer Treatment
Volume6
Issue number3
StatePublished - Dec 1 1993

Fingerprint

Adenocarcinoma
HSP27 Heat-Shock Proteins
Carcinoma
Malignant Fibrous Histiocytoma
Neoplasms
Rectum
Proteins
Lymph Nodes
Immunohistochemistry
Breast Neoplasms
Recurrence
Survival
Therapeutics

Keywords

  • heat shock protein 27
  • hsp-27
  • rectal carcinoma
  • srp-27
  • stress response protein 27

ASJC Scopus subject areas

  • Oncology
  • Pharmacology

Cite this

Storm, F. K., Mahvi, D. M., & Gilchrist, K. W. (1993). Hsp-27 is not expressed and has no prognostic significance in rectal adenocarcinoma. Regional Cancer Treatment, 6(3), 146-148.
Storm, F. K. ; Mahvi, D. M. ; Gilchrist, K. W. / Hsp-27 is not expressed and has no prognostic significance in rectal adenocarcinoma. In: Regional Cancer Treatment. 1993 ; Vol. 6, No. 3. pp. 146-148.
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Storm, FK, Mahvi, DM & Gilchrist, KW 1993, 'Hsp-27 is not expressed and has no prognostic significance in rectal adenocarcinoma', Regional Cancer Treatment, vol. 6, no. 3, pp. 146-148.

Hsp-27 is not expressed and has no prognostic significance in rectal adenocarcinoma. / Storm, F. K.; Mahvi, D. M.; Gilchrist, K. W.

In: Regional Cancer Treatment, Vol. 6, No. 3, 01.12.1993, p. 146-148.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hsp-27 is not expressed and has no prognostic significance in rectal adenocarcinoma

AU - Storm, F. K.

AU - Mahvi, D. M.

AU - Gilchrist, K. W.

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AB - This investigation involves the expression of heat shock protein 27 (hsp-27) in rectal carcinoma. Hsp-27 protein expression is correlated with prognosis in patients with node-negative breast cancer as well as malignant fibrous histiocytoma. It may be an important predictor of outcome in other high risk tumors which could influence the use of adjuvant therapy. Archival primary tumor specimens of 44 patients with previously untreated surgically resected adenocarcinoma of the rectum and 5-year minimum follow-up were evaluated by immunohistochemistry for hsp-27 expression. Patients were stratified by age, gender, degree of invasion and differentiation, lymph node status, local recurrence and survival. No tumor in this investigation expressed this protein to any significant degree. Hsp-27, therefore, has no value for predicting the outcome of patients with rectal carcinoma.

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