HTLV-1 and Adult T-cell leukemia/lymphoma: A review

F. Ravandi-Kashani, C. Sriswasdi, A. Lynott, F. J. Giles*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Infection with the human T-lymphotropic virus type 1 (HTLV-1) has been shown to be fundamental to the etiology of Adult T-cell Leukemia/Lymphoma (ATL). The disease is endemic in specific geographic areas but is increasingly reported from non-endemic regions. With increasing number of patients with this entity, the diversity in the clinical features has become apparent. In the past treatment strategies using combination chemotherapy have been unsatisfactory, but more recent trials using adenosine analouges, interferons, and combination of interferons and AZT have shown promise. With increased understanding of the etiology and molecular basis of the disease more effective therapies can be anticipated.

Original languageEnglish (US)
Pages (from-to)429-441
Number of pages13
JournalHematology
Volume3
Issue number6
DOIs
StatePublished - 1998

Keywords

  • ATL
  • Epidemiology
  • HTLV-1
  • Pathogenesis
  • Therapy

ASJC Scopus subject areas

  • Hematology

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