HTLV-III/LAV-Like retrovirus particles in the brains of patients with aids encephalopathy

Leon G. Epstein; Leroy R. Sharer; Eun Sook Cho; Marcus Myenhofer; Bradford A. Navia; Richard W. Price

doi:10.1089/aid.1.1983.1.447

HTLV-III/LAV-Like retrovirus particles in the brains of patients with aids encephalopathy

Leon G. Epstein, Leroy R. Sharer, Eun Sook Cho, Marcus Myenhofer, Bradford A. Navia, Richard W. Price

Pediatrics

Research output: Contribution to journal › Article › peer-review

188 Scopus citations

Abstract

It has been postulated that the retrovirus HTLV-III/LAV thought to be the etiologic agent of AIDS also infects the central nervous system and directly causes AIDS encephalopathy. Electron microscopical studies performed on brain sections from three patients with AIDS complicated by progressive encephalopathy revealed structures morphologically consistent with HTLV-III/LAV retrovirus particles. The particles were located principally within multinucleated giant cells but were also present in astrocytes. Many particles were also noted in the extracellular space.

Original language	English (US)
Pages (from-to)	447-454
Number of pages	8
Journal	AIDS Research
Volume	1
Issue number	6
DOIs	https://doi.org/10.1089/aid.1.1983.1.447
State	Published - Jan 1 1983

ASJC Scopus subject areas

Immunology
Virology

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10.1089/aid.1.1983.1.447

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title = "HTLV-III/LAV-Like retrovirus particles in the brains of patients with aids encephalopathy",

abstract = "It has been postulated that the retrovirus HTLV-III/LAV thought to be the etiologic agent of AIDS also infects the central nervous system and directly causes AIDS encephalopathy. Electron microscopical studies performed on brain sections from three patients with AIDS complicated by progressive encephalopathy revealed structures morphologically consistent with HTLV-III/LAV retrovirus particles. The particles were located principally within multinucleated giant cells but were also present in astrocytes. Many particles were also noted in the extracellular space.",

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AU - Epstein, Leon G.

AU - Sharer, Leroy R.

AU - Cho, Eun Sook

AU - Myenhofer, Marcus

AU - Navia, Bradford A.

AU - Price, Richard W.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - It has been postulated that the retrovirus HTLV-III/LAV thought to be the etiologic agent of AIDS also infects the central nervous system and directly causes AIDS encephalopathy. Electron microscopical studies performed on brain sections from three patients with AIDS complicated by progressive encephalopathy revealed structures morphologically consistent with HTLV-III/LAV retrovirus particles. The particles were located principally within multinucleated giant cells but were also present in astrocytes. Many particles were also noted in the extracellular space.

AB - It has been postulated that the retrovirus HTLV-III/LAV thought to be the etiologic agent of AIDS also infects the central nervous system and directly causes AIDS encephalopathy. Electron microscopical studies performed on brain sections from three patients with AIDS complicated by progressive encephalopathy revealed structures morphologically consistent with HTLV-III/LAV retrovirus particles. The particles were located principally within multinucleated giant cells but were also present in astrocytes. Many particles were also noted in the extracellular space.

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JO - AIDS Research

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ER -

HTLV-III/LAV-Like retrovirus particles in the brains of patients with aids encephalopathy

Abstract

ASJC Scopus subject areas

UN SDGs

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