Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection

Amy C. Sherman; Xiaoyan Lu; Eileen Schneider; Amelia Langston; Carla L. Ellis; Stephen Pastan; Julu Bhatnagar; Sarah Reagan-Steiner; Pallavi Annambhotla; Stephen Lindstrom; Aneesh Mehta; Stephanie M. Pouch; Marybeth E. Sexton

doi:10.1093/ofid/ofab092

Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection

Amy C. Sherman^*, Xiaoyan Lu, Eileen Schneider, Amelia Langston, Carla L. Ellis, Stephen Pastan, Julu Bhatnagar, Sarah Reagan-Steiner, Pallavi Annambhotla, Stephen Lindstrom, Aneesh Mehta, Stephanie M. Pouch, Marybeth E. Sexton

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. Methods: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed. Results: WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir. Conclusions: Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.

Original language	English (US)
Article number	ofab092
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	3
DOIs	https://doi.org/10.1093/ofid/ofab092
State	Published - Mar 1 2021

Keywords

adenovirus
brincidofovir
renal transplantation

ASJC Scopus subject areas

Clinical Neurology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/ofid/ofab092

Cite this

Sherman, A. C., Lu, X., Schneider, E., Langston, A., Ellis, C. L., Pastan, S., Bhatnagar, J., Reagan-Steiner, S., Annambhotla, P., Lindstrom, S., Mehta, A., Pouch, S. M., & Sexton, M. E. (2021). Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection. Open Forum Infectious Diseases, 8(3), Article ofab092. https://doi.org/10.1093/ofid/ofab092

@article{d80d1eef828e412e85a8dcb3ab04c7cc,

title = "Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection",

abstract = "Background: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. Methods: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed. Results: WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir. Conclusions: Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.",

keywords = "adenovirus, brincidofovir, renal transplantation",

author = "Sherman, {Amy C.} and Xiaoyan Lu and Eileen Schneider and Amelia Langston and Ellis, {Carla L.} and Stephen Pastan and Julu Bhatnagar and Sarah Reagan-Steiner and Pallavi Annambhotla and Stephen Lindstrom and Aneesh Mehta and Pouch, {Stephanie M.} and Sexton, {Marybeth E.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2021",

month = mar,

day = "1",

doi = "10.1093/ofid/ofab092",

language = "English (US)",

volume = "8",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Human Adenovirus 11 in 2 Renal Transplant Recipients

T2 - Suspected Donor-Derived Infection

AU - Sherman, Amy C.

AU - Lu, Xiaoyan

AU - Schneider, Eileen

AU - Langston, Amelia

AU - Ellis, Carla L.

AU - Pastan, Stephen

AU - Bhatnagar, Julu

AU - Reagan-Steiner, Sarah

AU - Annambhotla, Pallavi

AU - Lindstrom, Stephen

AU - Mehta, Aneesh

AU - Pouch, Stephanie M.

AU - Sexton, Marybeth E.

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Background: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. Methods: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed. Results: WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir. Conclusions: Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.

AB - Background: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. Methods: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed. Results: WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir. Conclusions: Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.

KW - adenovirus

KW - brincidofovir

KW - renal transplantation

UR - http://www.scopus.com/inward/record.url?scp=85105223156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85105223156&partnerID=8YFLogxK

U2 - 10.1093/ofid/ofab092

DO - 10.1093/ofid/ofab092

M3 - Article

C2 - 34386544

AN - SCOPUS:85105223156

SN - 2328-8957

VL - 8

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 3

M1 - ofab092

ER -

Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this