Human Adenovirus 11 in 2 Renal Transplant Recipients: Suspected Donor-Derived Infection

Amy C. Sherman*, Xiaoyan Lu, Eileen Schneider, Amelia Langston, Carla L. Ellis, Stephen Pastan, Julu Bhatnagar, Sarah Reagan-Steiner, Pallavi Annambhotla, Stephen Lindstrom, Aneesh Mehta, Stephanie M. Pouch, Marybeth E. Sexton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Human adenovirus (HAdV) infections can lead to high mortality in solid organ transplant (SOT) recipients, with rare reports of donor-derived infection. Methods: Two renal transplant recipients with HAdV-11 infection who received kidneys from the same donor are described. Whole-genome sequencing (WGS) was performed. Results: WGS showed 100% nucleotide sequence identity for the 2 HAdV-11 isolates. The patients presented with distinct clinical syndromes, and both were treated with brincidofovir. Conclusions: Donor-derived HAdV infection is presumed to be low; however, disseminated HAdV in SOT recipients can be severe, and clinicians should be aware of the clinical course and treatment options.

Original languageEnglish (US)
Article numberofab092
JournalOpen Forum Infectious Diseases
Volume8
Issue number3
DOIs
StatePublished - Mar 1 2021

Keywords

  • adenovirus
  • brincidofovir
  • renal transplantation

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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