Human allospecific cytolytic T lymphocyte lysis of a murine cell transfected with HLA-A2

T. D. Koller, C. Clayberger, J. L. Maryanski, A. M. Krensky

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A variety of molecules are involved in the interaction of human allospecific cytolytic T lymphocytes (CTL) with target cells. Monoclonal antibodies specific for these molecules inhibit CTL-target conjugate formation and/or lysis. To further study recognition and lysis of targets by human CTL, we used a murine mastocytoma cell line transfected with the histocompatibility leukocyte antigen (HLA)-A2 gene (P815-A2+) as a target for human HLA-A2-specific CTL. We find that only a subset of human HLA-A2-specific CTL can lyse murine P815-A2+ cells, suggesting that the murine cells may lack one or more accessory molecules needed for CTL recognition and lysis.

Original languageEnglish (US)
Pages (from-to)2044-2049
Number of pages6
JournalJournal of Immunology
Volume138
Issue number7
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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