Human auditory cortical activation during self-vocalization

Jeremy D.W. Greenlee, Adam W. Jackson, Fangxiang Chen, Charles R. Larson, Hiroyuki Oya, Hiroto Kawasaki, Haiming Chen, Matthew A. Howard

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Abstract

During speaking, auditory feedback is used to adjust vocalizations. The brain systems mediating this integrative ability have been investigated using a wide range of experimental strategies. In this report we examined how vocalization alters speech-sound processing within auditory cortex by directly recording evoked responses to vocalizations and playback stimuli using intracranial electrodes implanted in neurosurgery patients. Several new findings resulted from these high-resolution invasive recordings in human subjects. Suppressive effects of vocalization were found to occur only within circumscribed areas of auditory cortex. In addition, at a smaller number of sites, the opposite pattern was seen; cortical responses were enhanced during vocalization. This increase in activity was reflected in high gamma power changes, but was not evident in the averaged evoked potential waveforms. These new findings support forward models for vocal control in which efference copies of premotor cortex activity modulate sub-regions of auditory cortex.

Original languageEnglish (US)
Article numbere14744
JournalPloS one
Volume6
Issue number3
DOIs
StatePublished - Mar 10 2011

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Greenlee, J. D. W., Jackson, A. W., Chen, F., Larson, C. R., Oya, H., Kawasaki, H., Chen, H., & Howard, M. A. (2011). Human auditory cortical activation during self-vocalization. PloS one, 6(3), [e14744]. https://doi.org/10.1371/journal.pone.0014744