Human biotinidase isn't just for recycling biotin

Jeanne Hymes, Barry Wolf*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

For years, the major role of biotin has been as the coenzyme for four carboxylases in humans. Although there has been evidence that biotin might have other functions, none has been firmly established. The discovery that human serum biotinidase has biotinyl-transferase activity, in addition to biotinidase hydrolase activity, presents new possibilities for the role of biotinidase in biotin metabolism. Specific transfer of biotin to histones by biotinidase provides a possible explanation for why biotin is found in the nucleus and the nature of its role in the regulation of protein transcription. Future studies will help to determine the functions of biotinidase in biotin metabolism and in disease states.

Original languageEnglish (US)
Pages (from-to)485S-489S
JournalJournal of Nutrition
Volume129
Issue number2 SUPPL.
DOIs
StatePublished - 1999

Keywords

  • Biotin
  • Biotinidase
  • Histones
  • Hydrolase
  • Transferase

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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