TY - JOUR
T1 - Human cytomegalovirus-mediated immunomodulation
T2 - Effects on glioblastoma progression
AU - Foster, Haidn
AU - Ulasov, Ilya V.
AU - Cobbs, Charles S.
N1 - Funding Information:
Manuscript is funded by NIH R01 NS070289 (Charles S. Cobbs is PI).
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/8
Y1 - 2017/8
N2 - The presence of human cytomegalovirus (HCMV) and glioblastoma multiforme (GBM), first established in 2002, has developed into an area of considerable interest and controversy. Numerous studies have found evidence of possible HCMV infection of GBM tumor cells as well as myriad onco- and immunomodulatory properties exhibited by HCMV antigens and transcripts, while recent reports have failed to detect HCMV particles in GBM and question the virus' role in tumor progression. This review highlights the known immunomodulatory properties of HCMV, independent of GBM infection status, that help drive the virus from peripheral blood into the vital tissues and subsequently dampen local immune response, assisting GBM tumors in evading immune surveillance and contributing to the disease's poor prognosis. Emerging antiviral approaches to treating GBM, including antiviral drugs and immunotherapies directed against HCMV, are also examined.
AB - The presence of human cytomegalovirus (HCMV) and glioblastoma multiforme (GBM), first established in 2002, has developed into an area of considerable interest and controversy. Numerous studies have found evidence of possible HCMV infection of GBM tumor cells as well as myriad onco- and immunomodulatory properties exhibited by HCMV antigens and transcripts, while recent reports have failed to detect HCMV particles in GBM and question the virus' role in tumor progression. This review highlights the known immunomodulatory properties of HCMV, independent of GBM infection status, that help drive the virus from peripheral blood into the vital tissues and subsequently dampen local immune response, assisting GBM tumors in evading immune surveillance and contributing to the disease's poor prognosis. Emerging antiviral approaches to treating GBM, including antiviral drugs and immunotherapies directed against HCMV, are also examined.
KW - Glioblastoma multiforme
KW - Human cytomegalovirus
KW - Immunosuppression
UR - http://www.scopus.com/inward/record.url?scp=85020177130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020177130&partnerID=8YFLogxK
U2 - 10.1016/j.bbcan.2017.05.006
DO - 10.1016/j.bbcan.2017.05.006
M3 - Review article
C2 - 28554666
AN - SCOPUS:85020177130
VL - 1868
SP - 273
EP - 276
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
SN - 0304-419X
IS - 1
ER -