Human cytotoxic T‐lymphocytes specific for autologous follicular lymphoma recognize immunoglobulin in a major histocompatibility complex restricted fashion

Sandra Luna‐Finerman, Jeffrey E. Lee, Pamela K. Wesley, Carol Clayberger, Alan M. Krensky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background. Previously, autologous Burkitt lymphoma‐specific cytotoxic T‐lymphocytes (CTL) were found to express the gamma and delta T‐cell receptor and recognize tumor idiotype in a major histocompatibility complex (MHC) unrestricted fashion. Methods. In this study, the authors established autologous CTL lines and clones specific for a B‐cell follicular lymphoma. Results. These CTL are tumor specific and inhibited by antiimmunoglobulin monoclonal antibodies, but unlike the Burkitt lymphoma‐specific CTL, they are MHC restricted and express the alpha and beta T‐cell receptor. Conclusions. These studies suggest that different B‐cell lymphomas can induce CTL of different phenotypes and MHC restriction.

Original languageEnglish (US)
Pages (from-to)2181-2186
Number of pages6
JournalCancer
Volume70
Issue number8
DOIs
StatePublished - Oct 15 1992

Keywords

  • cytotoxic T‐lymphocytes
  • follicular lymphoma
  • histocompatibility antigen
  • idiotype
  • immunoglobulin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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