Human embryonic stem cells as a model for nutritional programming: An evaluation

Cinzia Allegrucci, Chris N. Denning, Paul Burridge, William Steele, Kevin D. Sinclair, Lorraine E. Young*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Our laboratory is evaluating whether an epigenetic mechanism involving alterations in DNA methylation can alter the trajectory of embryonic/fetal development in response to maternal nutrients. A similar mechanism may operate in embryo culture environments commonly used in human assisted conception. Since developmental studies on early human embryos in utero are obviously not possible, we have begun to investigate the utility of human embryonic stem cells (hESC) to uncover potential programming mechanisms. This review highlights some of the advantages and problems associated with such a model and suggests that these issues are also broadly applicable to utility of hESC for more general toxicology and drug screening applications.

Original languageEnglish (US)
Pages (from-to)353-367
Number of pages15
JournalReproductive Toxicology
Issue number3
StatePublished - Sep 2005


  • DNA methylation
  • Developmental origins of adult disease
  • Embryo
  • Folate
  • Human embryonic stem cells
  • Nutritional programming

ASJC Scopus subject areas

  • Toxicology


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