Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation

Jude Fitzgibbon, Elias Nicholas Katsanis, Dagan Wells, Joy Delhanty, William Vallins, David M. Hunt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Guanylate kinase (GK) catalyses the conversion of GMP to GTP as part of the cGMP cycle. In mammalian phototransduction, this cycle is essential for the regeneration of cGMP following its hydrolysis by phosphodiesterase. Mutations in different parts of this signalling cascade lead to retinal degeneration in humans. Protein studies have localized a locus for GK to a region of human chromosome 1 that also contains an autosomal recessive form of retinitis pigmentosa (RP12) and Usher's type 11a (USH2A). We report the sequence of this human GK (GUK1) and a further refinement of its localization to 1q32-41, placing it in the same interval as USH2A.

Original languageEnglish (US)
Pages (from-to)185-188
Number of pages4
JournalFEBS Letters
Volume385
Issue number3
DOIs
StatePublished - May 6 1996

Keywords

  • Usher's type 11a
  • cGMP cycle
  • guanylate kinase
  • phototransduction

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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