Human leucocyte antigens (HLA) and trimellitic anhydride (TMA) immunological lung disease

L. C. Grammer*, C. R. Zeiss, P. R. Yarnold, M. A. Shaughnessy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Occupational immunological lung disease, due to low molecular weight, reactive chemicals such as trimellitic anhydride (TMA), is an emerging health problem. If there were a marker that was highly predictive of the ability of the immune system to recognize TMA as an allergen, better prevention strategies could be employed with at risk individuals. The purpose of this study is to evaluate whether human leucocyte antigen (HLA) class specificity is associated with the development of late respiratory systemic syndrome (LRSS) or asthma due to immunological sensitivity to trimellitic anhydride (TMA). This is a case control study of 17 individuals with LRSS, 12 with asthma and 22 TMA similarly exposed individuals who did not develop LRSS or asthma. Comparing the sensitized individuals (LRSS or asthma) with the non-sensitized individuals (controls), we found no difference in frequency of any HLA antigen. In summary, the lack of association of HLA antigens with LRSS or asthma due to TMA suggests that these will not be useful markers to identify at risk individuals.

Original languageEnglish (US)
Pages (from-to)964-970
Number of pages7
JournalRespiratory Medicine
Issue number10
StatePublished - 2000


  • Asthma
  • HLA
  • Occupational disease
  • Trimellitic anhydride

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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